Sixtin 5mg Tablet | Type 2 Diabetes | Medicine | ePharma
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Sixtin 5mg Tablet

Generic: Saxagliptin

Type: Tablet

Pack Size: 10 Pcs

Type II Diabetes Mellitus is a condition in which your body cannot make or use the insulin it makes effectively, to move sugar from the blood into the cells for use as energy. Sixtin 5mg Tablet is used in the treatment of Type II Diabetes Mellitus.


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Discount Price: ৳ 279
MRP: ৳ 300 7% Off

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✅ Description:

Sixtin 5mg Tablet contains Saxagliptin which belongs to the group of medicines called Anti-diabetic drugs. It is used in adults (18 years and older) to treat type 2 diabetes that cannot be adequately controlled with one oral anti-diabetic medicine, diet, and exercise. It is used alone or together with insulin or other anti-diabetic medicines (Ex. metformin, sulfonylureas).

Type 2 diabetes is a condition in which your body does not make enough insulin (a hormone that helps control your blood sugar levels) or the insulin that is produced does not work to control glucose levels. It can show symptoms like increased thirst, urination, hunger, blurry vision, numbness in the hands or feet, or tiredness.

Appropriate diet and exercise can help your body use its blood sugar better. Follow any advice given by your doctor regarding skin and foot care. Before taking Sixtin 5mg Tablet, inform your doctor if you have any serious kidney, liver, or heart problems, reduced immunity, type-1 diabetes, or pancreatic problems.

Sixtin 5mg Tablet is not recommended for use during pregnancy and breastfeeding. Therefore, consult your doctor before taking it. Sixtin 5mg Tablet is not recommended for use in children and adolescents under 18 years of age.

Safety Advices


Alcohol
UNSAFE

Sixtin 5mg Tablet is not advised to be taken with alcohol as it causes bizarre interactions. Both hypoglycemia (low blood sugar) and hyperglycemia (high blood sugar) may occur, depending on how much and how often you drink.


Pregnancy
CONSULT YOUR DOCTOR
  • Caution is advised, and it's recommended to consult a doctor before taking Sixtin 5mg Tablet during pregnancy.
  • No harmful interactions have been reported in pregnant mothers, but precautionary consultation is suggested.

Breastfeeding
CONSULT YOUR DOCTOR
  • Caution is advised, and it's recommended to consult a doctor before taking Sixtin 5mg Tablet while breastfeeding.
  • No harmful interactions have been reported in breastfeeding mothers, but precautionary consultation is suggested.

Driving
CAUTION
  • Caution is recommended, especially if the patient feels dizzy while taking Sixtin 5mg Tablet.
  • Patients experiencing dizziness are advised not to drive or operate machinery.
  • Hypoglycemia may affect the ability to drive, especially when combined with other medicines known to cause hypoglycemia.

Kidney
CONSULT YOUR DOCTOR
  • Caution is advised for patients with kidney issues.
  • Patients with reduced kidney function are recommended to consult with a doctor before taking Sixtin 5mg Tablet, as the doctor may adjust the dose based on their judgment.

Liver
CONSULT YOUR DOCTOR
  • Caution is advised for patients with liver problems.
  • Patients with severe liver problems are not recommended to take Sixtin 5mg Tablet without consulting a doctor.

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✔️ Uses of Sixtin 5mg Tablet
  • Treat type 2 diabetes
✔️ How does Sixtin 5mg Tablet work?

Sixtin 5mg Tablet controls blood sugar levels by increasing the consumption of sugar by the body and reducing the production of sugar by the liver.

✔️ Side Effects of Sixtin 5mg Tablet

Common Side Effects:

  • Upper respiratory tract infection
  • Urinary tract infection
  • Headache
  • Dizziness
  • Diarrhea
  • Stomach pain

Stop taking Sixtin 5mg Tablet and contact your doctor immediately if you experience:

  • Low blood sugar (shaking, sweating, anxiety, blurred vision, tingling lips, paleness, mood change, vagueness, confusion, rapid heartbeat, hunger, or headache)
  • Serious allergic reaction (rash, raised red patches on your skin, swelling of the face, lips, tongue, and throat that may cause trouble breathing or swallowing)
  • Bullous pemphigoid symptoms such as skin blistering
  • Symptoms of heart failure (breathlessness, rapid increase in weight, and swelling of the feet)
  • Pancreatitis (inflammation of the pancreas)
  • Prolonged severe abdominal pain which may be accompanied by vomiting
  • Severe disabling joint pain
✔️ Quick Suggestions:
  • Saxagliptin should be taken at the same time every day since this helps you remember to take it.
  • Be careful while driving or operating machinery until you know how Saxagliptin affects you.
  • It may cause hypoglycemia (low blood sugar level) when used with other antidiabetic medicines, alcohol, or if you delay or miss a meal.
  • Always carry some sugary food or fruit juice with you in case you experience hypoglycemia symptoms such as cold sweats, cool pale skin, tremor, and anxiety.
  • Inform your doctor if you notice joint pains or develop symptoms such as stomach pain, nausea, and/or vomiting.
✔️ Indications:
  • Saxagliptin is used as an adjunct (supplement) to diet and exercise.
  • Its primary purpose is to enhance glycemic control in individuals diagnosed with type 2 diabetes mellitus.
  • Saxagliptin is not indicated for the treatment of type 1 diabetes mellitus.
  • It is not effective in managing diabetic ketoacidosis.
✔️ Pharmacology

Mechanism of Action:

  • Saxagliptin inhibits the enzyme dipeptidyl peptidase IV (DPP-4).
  • This inhibition leads to higher levels of active incretin hormones, specifically glucose-dependent insulinotropic polypeptide (GIP) and glucagon-like peptide-1 (GLP-1).

Physiological Effects:

  • Increased GIP and GLP-1 levels stimulate insulin production by pancreatic β-cells.
  • Insulin release occurs in a glucose-dependent manner, meaning it is triggered when blood glucose levels are elevated.
  • This mechanism helps lower both fasting and postprandial (after-meal) plasma glucose concentrations.

Therapeutic Impact in Type 2 Diabetes:

  • In individuals with type 2 diabetes, saxagliptin improves glycemic management.
  • The medication's effect on insulin regulation contributes to better control of blood sugar levels, addressing both fasting and post-meal glucose concentrations.

This mechanism is part of the broader class of DPP-4 inhibitors, which aim to enhance the body's own ability to regulate blood glucose levels in individuals with type 2 diabetes.

✔️ Dosage & Administration of Sixtin 5mg Tablet

Adult Dose:

  • Type 2 diabetes mellitus: The usual adult dose is 2.5 or 5 mg once daily.
  • Combination therapy: If used in combination with other medications, especially sulfonylurea or other insulin secretagogues, there may be a need to reduce the dosage of those medications.
  • Coadministration with strong CYP450 3A4/5 inhibitors: The dose should not exceed 2.5 mg once daily.
  • Elderly: No dosage adjustment is necessary for elderly individuals.
  • Hepatic Impairment: No dosage adjustment is specified for hepatic impairment.

Child Dose:

  • The safety and efficacy of the medication have not been established in individuals under 18 years of age.

Renal Dose:

  • Renal impairment (Creatinine Clearance, CrCl):
    • CrCl >50 mL/min: No dose adjustment is required.
    • CrCl <50 mL/min: The dose should not exceed 2.5 mg once daily.
  • End-Stage Renal Disease (ESRD):
    • The specific dose adjustment for ESRD is not provided in the given information.
✔️ Interaction

Drug-Drug Interactions:

Before taking Sixtin 5mg Tablet inform your doctor if you are taking any of the following medicines:

Carbamazepine, phenobarbital, or phenytoin:

  • Used to control fits (seizures) or chronic pain.

Dexamethasone:

  • Used to treat inflammation.

Rifampicin:

  • Used to treat infections such as tuberculosis.

Ketoconazole:

  • Used to treat fungal infections.

Diltiazem:

  • Used to lower blood pressure.
✔️ Contraindications
  • Hypersensitivity: This refers to an exaggerated immune response to a substance, in this case, the medication. It can manifest as various allergic reactions.
  • Anaphylaxis: Anaphylaxis is a severe, potentially life-threatening allergic reaction that can occur rapidly and affect the whole body. It requires immediate medical attention.
  • Angioedema: Angioedema is a condition characterized by the rapid swelling of the deeper layers of the skin, often occurring around the eyes and lips. It can also involve the throat and cause difficulty breathing.
  • Exfoliative skin conditions: This term generally refers to conditions where there is widespread shedding or peeling of the skin.
✔️ Pregnancy & Lactation

Animal reproduction studies have not shown a risk to the fetus, and there are no adequate and well-controlled studies in pregnant women. However, it's essential to note that animal studies do not always predict the same effects in humans. There may be limited data from human pregnancy studies, especially in the first trimester, and there is no evidence of risk in later trimesters.

✔️ Precautions & Warnings
  • Not recommended for use by pregnant or breastfeeding women.
  • Use with caution if you feel dizzy (hypoglycemic) after taking the medication.
  • Consult your doctor before using if you have kidney or liver problems.
  • Not recommended for use in patients with severe liver problems.
✔️ Storage Conditions

Store between 20-25° C.

Frequently Asked Questions (FAQ)

Sixtin 5mg Tablet when taken with insulin can help in lowering the insulin dose and decrease the risk of hypoglycemia (low blood sugar levels). Consult your doctor as a dose adjustment of the two may be needed.

Yes, Saxagliptin can be used alone or in combination with other diabetes medicines, along with proper diet and exercise.

No, Sixtin 5mg Tablet is recommended for use by adults only and is not recommended for children and adolescents below 18 years of age, as its safety and effectiveness in children have not been studied. Your doctor will determine the correct dose or select a suitable alternative therapy for your child.
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Check our pricing section for Sixtin 5mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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