Insul TM Glargine is indicated for once-daily subcutaneous administration for the treatment of adult and pediatric patients with type 1 diabetes mellitus or adult patients with type 2 diabetes mellitus who require basal (long-acting) insulin for the control of hyperglycemia.
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Insul TM Glargine 100IU/ml SC Injection 3ml is a synthetic insulin-containing insulin glargine, designed to mimic human insulin. Used to treat diabetes in adults and children aged two years and above, it ensures steady blood sugar control without peaks. This long-acting insulin takes around 2 hours to begin working and lasts up to 24 hours.
Your doctor will determine your dosage based on lifestyle, blood sugar tests, and previous insulin use. Injection site reactions and hypoglycemia may occur, but most resolve over time. Don't stop using it abruptly, and inform your doctor if you experience persistent side effects.
Avoid using Insul TM Glargine 100IU/ml SC Injection for low blood sugar, kidney/liver/heart issues, or alcohol/drug problems. Complement it with a healthy diet, regular exercise, and weight management.
Taking Insulin Glargine with alcohol may affect blood glucose levels in patients with diabetes.
Insul TM Glargine 100IU/ml SC Injection 3ml may be unsafe to use during pregnancy. Animal studies have shown adverse effects on the fetus, however, there are limited human studies. The benefits from use in pregnant women may be acceptable despite the risk. Please consult your doctor.
Insul TM Glargine 100IU/ml SC Injection 3ml is safe to use during lactation. Human studies have shown that either the drug does not pass into the breastmilk in significant amounts or is not expected to cause toxicity to the baby.
Insul TM Glargine 100IU/ml SC Injection 3ml may make you feel dizzy, sleepy, tired, or decrease alertness. If this happens, do not drive.
Insul TM Glargine 100IU/ml SC Injection 3ml should be used with caution in patients with kidney disease. Dose adjustment of Insul TM Glargine 100IU/ml SC Injection 3ml may be needed. Please consult your doctor. Regular monitoring of blood glucose levels is recommended for dose adjustment.
Insul TM Glargine 100IU/ml SC Injection 3ml should be used with caution in patients with liver disease. A dose adjustment of Insul TM Glargine 100IU/ml SC Injection 3ml may be needed. Please consult your doctor. Regular monitoring of glucose levels is recommended for dose adjustment.
Insul TM Glargine 100IU/ml SC Injection is a long-acting modified form of insulin that works similarly to human insulin. It improves blood sugar control by enhancing glucose uptake from the blood into body tissues and also by preventing the production of glucose in the liver.
Hypoglycemia (low blood sugar level), Injection site allergic reaction.
Insulin Glargine is employed to manage both Type 1 Diabetes mellitus and Type 2 Diabetes Mellitus:
Type 1 Diabetes Mellitus:
In this lifelong condition, the pancreas fails to produce enough insulin to regulate blood sugar levels. Insulin Glargine is used to supplement inadequate insulin production and maintain appropriate blood sugar levels.
Type 2 Diabetes Mellitus:
This chronic condition involves cells being unable to effectively use the insulin produced by the body, leading to improper conversion of glucose into energy. Insulin Glargine helps in managing blood sugar levels by providing the needed insulin support to overcome this resistance.
Insulin Glargine is a sterile solution for subcutaneous injection, designed to lower blood glucose levels. It's a long-acting insulin with up to 24 hours duration, produced using recombinant DNA technology. Its mechanism involves enhancing glucose absorption in muscles and fat, lowering hepatic glucose production, and supporting protein synthesis while inhibiting lipolysis and proteolysis.
Interactions with Other Medicines:
Interactions with Food Items:
Clinical studies on the use of insulin glargine in pregnant women have not been well-controlled. It's crucial for individuals with diabetes or a history of gestational diabetes to maintain optimal metabolic control before conception and throughout pregnancy. Insulin requirements may vary, typically decreasing in the first trimester, increasing in the second and third trimesters, and rapidly decreasing post-delivery. Close monitoring of glucose control is vital in these cases.
Due to the limited predictive value of animal studies for human response, insulin glargine should only be used during pregnancy if clearly necessary. The extent of insulin glargine excretion in human milk is unknown, but it's noted that various drugs, including human insulin, are present in human milk. Thus, caution is advised when administering InsulTM Glargine to nursing women, who might require insulin dose and diet adjustments.
Hypoglycemia, characterized by low blood sugar levels, is a common adverse effect of insulin therapies, including Insul TM Glargine. The timing of hypoglycemia may vary among different insulin formulations. Regular glucose monitoring is advised for all diabetes patients. Any changes in insulin should be done cautiously under medical supervision. Alterations in insulin strength, dosing timing, manufacturer, type, species, or manufacturing method may necessitate dosage adjustments. InsulTM Glargine should not be mixed with other insulins or solutions to avoid unpredictable changes in its pharmacokinetics and pharmacodynamics. Intravenous administration of InsulTM Glargine is prohibited due to the risk of severe hypoglycemia.
The onset and duration of Insul TM Glargine's action can vary based on factors such as blood supply, temperature, and physical activity. Insulin might cause sodium retention and edema, especially if improved metabolic control leads to intensified therapy. Hypoglycemic reactions can occur with all insulin preparations, particularly in cases of rapid changes in blood glucose levels. Early warning signs of hypoglycemia may vary under certain conditions. Renal impairment can reduce insulin requirements, while hepatic impairment doesn't affect InsulTM Glargine's absorption but may require dose adjustments.
Store uInsul TM Glargine 100IU/ml SC Injection 3ml in the fridge (2-8°C), avoiding the freezer, to maintain its effectiveness.
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