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Retigel 0.05% Topical Gel 20gm Tube
Retigel Topical Gel is prescribed for treating mild to moderate inflammatory and non-inflammatory acne vulgaris.
Use this medication only under the guidance of a registered medical practitioner.
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✅ Description:
Isotretinoin works by influencing cell cycle progression, differentiation, survival, and apoptosis, which collectively reduce sebum production. This action helps prevent clogged pores and limits the proliferation of acne-causing bacteria. Both isotretinoin and its metabolite, 4-oxo-isotretinoin, significantly decrease sebum production. Isotretinoin exhibits minimal binding to retinol-binding proteins (RBPs) and retinoic acid nuclear receptors (RARs), while tretinoin and 4-oxo-tretinoin selectively bind to the RAR-γ receptor, which may contribute to its anti-acne properties. By inducing apoptosis in sebocytes, it further reduces sebum levels. It also minimizes comedone formation by reducing hyperkeratinization through an unknown mechanism. Although isotretinoin does not directly kill bacteria, it creates an environment less favorable for bacterial growth by shrinking sebum ducts. Additionally, it may enhance immune responses and alter monocyte chemotaxis to reduce inflammation.
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✔️ Dosage and Administration of Retigel 0.05% Topical Gel
- Apply Isotretinoin 0.05% gel sparingly to the affected areas once or twice daily.
- Patients should be informed that it may take 6–8 weeks to observe a therapeutic effect.
- The safety and efficacy of this medication in children have not been established, as acne vulgaris is rare in this age group.
- There are no specific dosage adjustments for elderly patients, as acne vulgaris typically does not occur in this population.
Use this medication only under the guidance of a registered medical practitioner.
✔️ Overdose Effects of Retigel 0.05% Topical Gel
- Overdose has not been reported with Retigel. However, accidental ingestion could lead to symptoms of hypervitaminosis A, including severe headaches, nausea, vomiting, drowsiness, irritability, and itching.
✔️ Side Effects of Retigel 0.05% Topical Gel
- Common side effects include stinging, burning, or irritation at the application site.
- Erythema and peeling may occur.
- If excessive irritation develops, temporarily stop using the gel and resume once symptoms subside. If irritation persists, discontinue use altogether.
✔️ Drug Interactions
- Use caution when combining Retigel with other topical medications.
- Special care is needed when using products containing peeling agents (e.g., benzoyl peroxide) or abrasive cleansers.
✔️ Contraindications
Not suitable for patients with a known hypersensitivity to isotretinoin.
✔️ Pregnancy and Lactation
- Pregnancy Category B: Although systemic isotretinoin is linked to teratogenicity, percutaneous absorption from the gel is negligible. However, due to limited safety data, its use should be avoided during pregnancy.
- It is unclear if isotretinoin is excreted in human milk; therefore, it is not recommended during lactation.
✔️ Precautions and Warnings
- Avoid contact with the eyes, mouth, mucous membranes, and broken or eczema-affected skin.
- Do not let the gel accumulate in skin folds or sensitive areas (e.g., neck, nasal creases).
- Protect treated areas from sunlight by using sunscreen and wearing protective clothing.
- Do not use this product on sunburned skin or while using tanning lamps.
- Patients with a history of cutaneous tumors should use Retigel cautiously.
✔️ Storage Conditions
- Store in a cool, dry place, protected from light.
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