Tretin Cream 0.025%

✔️ Uses:

• Acne
• Wrinkles

✔️ How does Tretin Cream 0.025% work?

Tretinoin affects the growth of skin cells, aiding in the treatment of acne pimples and contributing to skin rejuvenation.

✔️ Side Effects of Tretin Cream 0.025%

• Common Side Effects: Dry skin, peeling, redness, burning, itching, or stinging sensation.
• Duration: Most side effects resolve over time without medical intervention.
• Persistent Side Effects: Consult a doctor if side effects persist or worsen.

✔️ Quick Suggestions:

• Use water and a non-medicated soap to clean the affected area.
• Allow 20-30 minutes for the area to dry before applying Tretin 0.025% Cream.
• It may increase the severity of spots or pimples in the initial weeks.
• Continue usage as prescribed by your doctor despite initial reactions.
• May cause a stinging sensation or warmth initially.
• Inform your doctor if these sensations persist.
• Avoid exposure to sunlight during Tretin 0.025% Cream use.
• Use sunscreen or protective clothing to counter increased skin sensitivity.
• Avoid face waxing and laser treatments as Tretin 0.025% Cream makes the skin more fragile.
• Avoid taking tetracycline (e.g., doxycycline) as it may reduce Tretin 0.025% Cream activity.

✔️ Acne:

Acne is a prevalent skin condition that arises when hair follicles are obstructed by dead skin cells and oil, leading to the development of pimples, whiteheads, and blackheads. Although acne can affect individuals of all ages, it is most commonly observed among teenagers. The symptoms of acne encompass a variety of manifestations, including pus-filled pimples, non-inflamed blackheads, as well as red, sizable, and tender bumps. The severity and persistence of acne can vary, necessitating different forms of treatment depending on individual cases.

✔️ Pharmacology

While the exact mechanism of action of Tretinoin is not fully understood, available evidence suggests that topical Tretinoin exerts its effects by influencing the behavior of follicular epithelial cells, ultimately contributing to the reduction of microcomedo formation. Additionally, Tretinoin stimulates mitotic activity and enhances the turnover of follicular epithelial cells. These actions collectively result in the removal of comedones (clogged hair follicles), papules (small, raised skin lesions), and pustules (pus-filled bumps) associated with conditions such as acne vulgaris.

✔️ Dosage of Tretin Cream 0.025%

• Follow your doctor's prescription for using Tretinoin 0.025% Cream.
• Full benefits may require 8 to 12 weeks of continuous application.

✔️ Direction For Use:

• Clean and dry the acne-prone skin area before applying the cream.
• Apply a thin layer of Tretin 0.025% Cream as prescribed by your doctor.
• Wash hands before and after application.
• Application is generally recommended at night for optimal results.
• Avoid contact with eyes, nose, mouth, or broken skin. Rinse thoroughly with water in case of accidental contact.

✔️ Interaction

Drug Interactions with Tretin 0.025% Cream 30gm:

• Vitamin A-Related Drugs (Retinoids): Tretin 0.025% Cream 30 gm may interact with other vitamin A-related drugs, such as isotretinoin. Caution is advised when using multiple retinoids simultaneously.
• Photosensitizing Agents: Tretin 0.025% Cream 30 gm may interact with photosensitizing agents like aminolevulinic acid, methoxsalen, porfirmer, and verteporfin. These interactions could potentially increase sensitivity to light.
• Sensitizer: Interaction with the sensitizer methyl aminolevulinate is mentioned. Specific details about the nature of this interaction should be discussed with a healthcare professional.
• Keratolytic Agents: Concurrent use of Tretin 0.025% Cream 30 gm with keratolytic agents like benzoyl peroxide, salicylic acid, and sulfur is noted. These combinations may impact skin treatment, and caution is advised.
• Antiseptic: Interaction with the antiseptic resorcinol is mentioned. The combined use of Tretin 0.025% Cream and resorcinol should be approached with caution, and medical guidance may be necessary.

Food Interactions: No specific interactions with food have been identified.

Disease Interactions: If you have eczema or any other skin condition, it's important to inform your doctor before using Tretin 0.025% Cream 30 gm. Pre-existing skin conditions may affect the suitability or dosage of the medication.

✔️ Contraindications

Avoid Tretin 0.025% Cream if you are allergic to it.

✔️ Pregnancy & Lactation

There is insufficient evidence regarding the safety of topically applied Tretinoin during human pregnancy. Tretinoin has been associated with teratogenicity (the potential to cause malformations in a developing embryo or fetus) when administered systemically.

Due to the potential risks associated with Tretinoin, particularly in systemic use, the cream is not recommended for use during pregnancy and lactation.

Teratogenic effects refer to the potential of a substance to cause malformations in a developing fetus. This risk is a significant concern with the systemic use of Tretinoin.

✔️ Precautions & Warnings

• Caution: Avoid sun exposure during Tretin 0.025% Cream 30 gm use.
• Sensitivity: Increases skin sensitivity to sunlight.
• History of Depression: Use with caution in patients with a history of depression.
• Eczema: Use with caution in patients with a history of eczema.
• Skin Cancer: Use with caution in patients with a history of skin cancer.
• Fish Allergies: Use with caution in patients with fish allergies.
• Protective Measures: Wear protective clothing and use sunscreen lotion (SPF) to prevent sunburn.

✔️ Storage Conditions

Store below 30°C