Zonyra 0.005% Cream

✔️ Uses of Zonyra 0.005% Cream

• Psoriasis
• Acne

✔️ How does

The precise mechanism of action of this medication has not yet been determined fully. According to studies, the active constituent of this medication when activated combines with all members of the receptor family, retinoic acids such as RARa, RARb, and RARg.

✔️ Side Effects of Zonyra 0.005% Cream

• Dry skin
• Erythema (skin redness)
• Itching
• Irritation
• Skin irritation
• Skin burns
• Skin peeling (loss of the upper layer of skin)

✔️ Quick Suggestions:

• Trifarotene should be applied as per dose and duration suggested by the doctor.
• Finish the full course of treatment even if you feel better.
• Wash your hands properly before and after applying the medicine.
• Avoid getting in the eyes, nose, or mouth. If accidental exposure occurs, rinse immediately with plenty of water.
• Avoid exposing your skin to strong sunlight, use a sunscreen lotion, or make sure your skin is protected with clothing.
• Do not cover the area being treated with airtight dressings such as bandages unless directed by a doctor, as this may increase the risk of side effects.
• Inform your doctor if the infection has not cleared up after four weeks of treatment.

✔️ Indication of Zonyra 0.005% Cream

Trifarotene cream is a retinoid indicated for the topical treatment of acne vulgaris in patients 9 years of age and older.

✔️ Pharmacology

Trifarotene is an agonist of retinoic acid receptors (RAR), with particular activity at the gamma subtype of RAR. Stimulation of RAR results in modulation of target genes which are associated with various processes, including cell differentiation and mediation of inflammation. The exact process by which Trifarotene ameliorates acne is unknown.

✔️ Dosage & Administration of Zonyra 0.005% Cream

• Apply a thin layer of Trifarotene cream to the affected areas once daily, in the evening, on clean and dry skin.
• The use of a moisturizer is recommended as frequently as needed from the initiation of treatment.
• Avoid contact with the eyes, lips, paranasal creases, and mucous membranes.
• Trifarotene cream is intended for topical use only. Not for oral, ophthalmic, or intravaginal use.

Pediatric Use: 

• The safety and effectiveness of Trifarotene cream have not been established in pediatric patients below the age of 9 years.

Geriatric Use: 

• Clinical trials of Trifarotene cream did not include any subjects aged 65 years and over to determine whether they respond differently than younger subjects.

✔️ Interaction

• Zonyra 0.005% Cream may interact with certain medications, including diuretics, antibiotics, antipsychotics, and medicines for psoriasis or dandruff. It is important to inform your doctor about all the medications you are taking to avoid any potential interactions.
• As for drug-food interactions, no interactions have been reported for Zonyra 0.005% Cream with food.
• Patients with eczema or sunburn should use Zonyra 0.005% Cream with caution, as it may exacerbate these conditions. It's essential to discuss your medical history with your doctor before using the gel to ensure its safe and effective use.

✔️ Contraindications

• If you are allergic to Trifarotene or any other ingredient of Zonyra 0.005% Cream.
• If you are pregnant, planning pregnancy, or breastfeeding women.

✔️ Pregnancy & Lactation

Pregnancy Category C. Available data from clinical trials with Trifarotene cream use in pregnant women have not identified a drug-associated risk of major birth defects, miscarriage, or adverse maternal or fetal outcomes. The developmental and health benefits of breastfeeding should be considered along with the mother’s clinical need for Trifarotene cream and any potential adverse effects on the breastfed infant from Trifarotene cream or from the underlying maternal condition.

✔️ Precautions & Warnings

Skin irritation: Patients using Trifarotene cream may experience erythema, scaling, dryness, and stinging/burning. Maximum severity of these reactions typically occurred within the first 4 weeks of treatment, and severity decreased with continued use of the medication. Depending upon the severity of these adverse reactions, instruct patients to use a moisturizer, reduce the frequency of application of Trifarotene cream or suspend use temporarily. If severe reactions persist the treatment may be discontinued. Avoid application of Trifarotene cream to cuts, abrasions, or eczematous or sunburned skin. Use of "waxing" as a depilatory method should be avoided on skin treated with Trifarotene cream.

Ultraviolet Light and Environmental Exposure: Minimize unprotected exposure to ultraviolet rays (including sunlight and sunlamps) during treatment with Trifarotene cream. Warn patients who normally experience high levels of sun exposure and those with inherent sensitivity to the sun to exercise caution. The use of sunscreen products and protective clothing over treated areas is recommended when exposure cannot be avoided.

✔️ Storage Conditions

Do not store above 25°C. Protect from light. Keep out of reach of children.