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Zystroin 20 belongs to a class of drugs called retinoids, which are derivatives of vitamin A. It is primarily used to treat severe, recalcitrant nodular acne that has not responded to other treatments, including systemic antibiotics. It is a potent medication, and its use requires close medical supervision due to potential side effects and contraindications.
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✅ Description:
- Zystroin 20 reduces sebum production by shrinking sebaceous glands.
- It regulates cell proliferation and differentiation, reducing blockages that cause acne.
- Acts as an anti-inflammatory agent to reduce redness and swelling.
- Take Zystroin 20 with food for better absorption.
- Stay hydrated and use a moisturizer to manage dryness of the skin, lips, and eyes.
- Avoid donating blood during treatment and for 1 month after stopping to prevent birth defects in pregnant transfusion recipients.
- Report any mood changes or signs of depression to your doctor immediately.
- If you miss a dose, take it as soon as you remember. Do not double doses.
Safety Advices
Alcohol
UNSAFE
Caution is advised with alcohol. Consult your doctor before consumption.
Pregnancy
CONSULT YOUR DOCTOR
Zystroin 20 is highly teratogenic (causes birth defects). It is strictly contraindicated during pregnancy. Women of childbearing potential must adhere to effective contraceptive measures (two forms of contraception) for at least 1 month before, during, and 1 month after treatment.
Breastfeeding
CONSULT YOUR DOCTOR
Limited evidence suggests Zystroin 20 may pass into breast milk and harm the infant.
Driving
CAUTION
May impair night vision suddenly, cause dizziness, or lead to drowsiness. Exercise caution while driving or using machinery.
Kidney
CAUTION
Dose adjustments may not be necessary, but consult your doctor if you experience symptoms such as extreme fatigue, swelling, or difficulty urinating.
Liver
CAUTION
Avoid in patients with severe liver impairment.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Composition
Isotretinoin
✔️ Uses
Severe acne (nodular or recalcitrant) that is resistant to conventional treatments.
✔️ Consult Your Doctor If You Experience:
- Persistent headache, vomiting, or visual disturbances.
- Severe abdominal pain, rectal bleeding, or jaundice.
- Signs of an allergic reaction (rash, swelling, or difficulty breathing).
✔️ Common Side Effects (>10%):
- Skin-related: Dry skin, chapped lips (cheilitis), rashes, peeling, redness, photosensitivity.
- Systemic: Increased liver enzymes, hypertriglyceridemia, and low HDL cholesterol.
- Musculoskeletal: Joint and muscle pain.
- Ocular: Dry eyes, conjunctivitis.
Rare but Serious Side Effects:
- Severe depression, psychosis, or suicidal ideation.
- Vision issues, such as sudden night blindness.
- Hemorrhagic pancreatitis or severe gastrointestinal issues.
- Premature closure of growth plates in children.
✔️ Dosage & Administration
Adult Dose:
- Initial dose: 0.5–1 mg/kg/day orally in two divided doses for 15–20 weeks.
- In cases of severe acne with scarring, the dose can be increased to 2 mg/kg/day (if tolerated).
Child Dose (>12 years):
- Same as the adult dose. Safety and efficacy are not established in children under 12.
Renal Impairment:
- Start with a reduced dose (e.g., 10 mg daily) and titrate gradually to a maximum of 1 mg/kg/day as needed.
✔️ Drug Interactions:
- Vitamin A derivatives: Additive toxicity—avoid concurrent use.
- Tetracyclines: Increased risk of intracranial hypertension.
- Phenytoin or corticosteroids: Increased risk of osteoporosis.
- Carbamazepine: Reduced efficacy due to interaction.
✔️ Precautions:
- Avoid prolonged sun exposure—use sunscreen and protective clothing.
- Avoid waxing, laser treatments, or harsh exfoliation during and for 6 months post-treatment, as the skin becomes fragile.
- Do not use tetracyclines concurrently (increased risk of pseudotumor cerebri).
- Monitor liver function tests (LFTs), triglycerides, and glucose levels periodically.
- Patients with psychiatric disorders or a history of depression/anorexia nervosa should be closely monitored.
✔️ Storage Instructions:
- Store in a cool, dry place away from light and moisture.
- Keep out of reach of children.
