Adryl Syrup 100ml

✔️ Uses of Adryl Syrup

Treatment of-

• Nasal allergy symptoms
• Cough
• Motion Sickness

✔️ Side Effects of Adryl Syrup

• Stomach pain/epigastric pain
• Sleepiness
• Dizziness
• Dry mouth
• Headache
• Nausea, vomiting
• Gastrointestinal discomfort
• Impaired coordination
• Thickened respiratory tract secretions

✔️ How does Adryl Syrup work?

Diphenhydramine is an antiallergic which relieves allergy symptoms like runny nose, watery eyes, and sneezing.

✔️ Quick Suggestions:

• To help alleviate congestion and soothe your throat, it is recommended to drink warm water while you are taking Adryl Syrup.
• Take Adryl Syrup exactly as directed by your doctor or as indicated on the label. Avoid increasing the dosage or taking it for a longer duration than recommended.
• When measuring the dosage, use a proper measuring cup or spoon to ensure accurate measurement.
• Most coughs typically resolve within 2 weeks. If your cough persists beyond this timeframe, it is advisable to consult your doctor for further evaluation.
• Inform your doctor if you have a history of stomach ulcers or asthma, as these conditions may require special consideration when using Adryl Syrup.
• It is important to inform your doctor about all the medications you are currently taking, including any antidepressants or other drugs, as there may be potential interactions between Adryl Syrup and other medications.
• Remember to follow your doctor's instructions and consult them if you have any concerns or questions regarding the use of Adryl Syrup.

✔️ Indication

Diphenhydramine Hydrochloride helps to treat-

• Vasomotor rhinitis can be seasonal or persistent.
• Urticaria, angioneurotic edema, and anaphylaxis are all symptoms of an allergic reaction.
• Pruritic symptoms
• Prescriptions for emesis and motion sickness are available.
• Meniere's disease and Parkinsonism are examples of miscellaneous conditions.

✔️ Pharmacology

Diphenhydramine is an antihistamine medication that exhibits sedative and anticholinergic properties. It works by binding to H1-receptor sites, competing with histamine. By blocking these receptors, diphenhydramine helps to alleviate allergic reactions and symptoms associated with histamine release, such as itching, sneezing, runny nose, and watery eyes. Its sedative properties make it useful for the temporary relief of occasional sleeplessness or insomnia. Additionally, its anticholinergic effects contribute to its ability to relieve symptoms like nausea, vomiting, and motion sickness.

✔️ Dosage & Administration of Adryl Syrup

Adult Dose:

• Allergic conditions; Treatment and prophylaxis of motion sickness: 25-50 mg taken orally 3-4 times daily. For prevention of motion sickness, take 30 minutes before exposure to motion. The maximum daily dose should not exceed 300 mg.
• Parkinson's disease: Initially, take 25 mg three times daily. The dosage may be increased to 50 mg four times daily if necessary.
• Short-term management of insomnia: Take 50 mg 30 minutes before bedtime as needed.
• Hepatic impairment: No dosage adjustment is needed for individuals with hepatic impairment.

Child Dose:

• Allergic Reaction:
  • 2-6 years: Take 6.25 mg every 4-6 hours. The maximum daily dose should not exceed 37.5 mg.
  • 6-12 years: Take 12.5-25 mg every 4-6 hours. The maximum daily dose should not exceed 150 mg.

12 years: Take 25-50 mg every 4-6 hours. The maximum daily dose should not exceed 300 mg.

• Occasional Insomnia:

12 years: Take 50 mg 30 minutes before bedtime.

• Cough:
  • <12 years: Safety and efficacy have not been established.

12 years: Take 25-50 mg every 4-6 hours. The maximum daily dose should not exceed 300 mg.

• Motion Sickness: Administer 30 minutes before motion.
  • 12.5-25 mg every 6-8 hours or 150 mg/m². The maximum daily dose should not exceed 300 mg.

Renal Dose:

• No dosage adjustment is needed for individuals with renal impairment.

Administration:

• Shake well before use. Your physician will decide the correct dose and duration for you depending on your age, body weight, and disease condition.
• Adryl Syrup may be taken with or without food.

✔️ Interaction

• Some medicines can affect the way Adryl Syrup works, or this medicine itself can reduce the effectiveness of other medicines taken at the same time.
• Tell your doctor about all the medicines, supplements, or herbals you are currently taking or might take to avoid any possible interaction
• Adryl Syrup should not be used concomitantly with MAO inhibitors like Selegiline and Isocarboxazid (used for psychiatric illness). It produces a condition called serotonin syndrome which is a life-threatening condition that can occur rapidly due to a build-up of an excessive amount of serotonin in the body. In serotonin syndrome, a person may experience high body temperature, high blood pressure, fast heart rate, excitability, tremor (shakiness), and sweating. In such a situation, patients should rush to a nearby hospital immediately.
• Concomitant use of this medicine with other anti-allergic medicines like Cetirizine, medicines like Atropine, Benztropine (used to treat travel or motion sickness, stomach cramps, and Parkinson’s disease), opioids like Codeine, Morphine (to relieve severe painful conditions), medicines like Propranolol, Metoprolol (used to treat heart problems, to decrease blood pressure) and may alter the effects of this medicine.
• Other medicines like Amitriptyline, Doxepin, and Ephedrine should be used with caution.

✔️ Contraindications

• If you are allergic to diphenhydramine, the ingredients of Adryl Syrup.
• If you are taking medicines like MAO inhibitors (Selegiline, Phenelzine, etc) which are used for psychiatric illness.
• If you have glaucoma (increased pressure in the eye which produces painful, red eyes and gradual vision loss).
• If you have ulcers in the stomach and intestine (symptoms like vomiting, acidity, indigestion, bleeding, black stool) or any problems related to your stomach.
• If you have prostate problems (conditions like benign prostatic hyperplasia which is characterized by difficulty in urination, frequent urge to go to urination, and dribbling of urine).
• If you have liver or kidney problems.
• If you have an asthma attack.
• If you are breastfeeding.
• If you are taking other sedating antihistamines medicines like Promethazine and Chlorpheniramine.

✔️ Pregnancy & Lactation

Category B: There are no appropriate and well-controlled studies of diphenhydramine hydrochloride in pregnant women. As a result, diphenhydramine hydrochloride should only be used during pregnancy if absolutely necessary. Diphenhydramine hydrochloride has been known to be excreted in breast milk, hence it is not recommended for use by nursing mothers.

✔️ Precautions & Warnings

Inform your doctor about your current medications, over-the-counter products (e.g., vitamins, herbal supplements, etc.), allergies, pre-existing diseases, and current health conditions before using Adryl Syrup (e.g. pregnancy, upcoming surgery, etc.). Some medical conditions may make you more susceptible to the drug's side effects. Take as directed by your doctor or as directed on the product insert. The dosage is determined by your medical condition. Inform your doctor if your condition worsens or persists. The following are important counseling points. 

• 65 years old or older
• Asthma
• Breastfeeding
• Bronchitis is chronic
• Urination difficulties
• Emphysema
• Glaucoma
• Cardiovascular disease
• High Blood Pressure
• Lung cancer

✔️ Storage Conditions

Medicines should be stored at room temperature, away from heat and direct light. Unless otherwise specified in the package insert, do not freeze medications. Keep medicines out of the reach of children and pets.