Avil (45.5mg/2ml) Injection 1pc

✔️ Uses of Avil (45.5mg/2ml) Injection

• Allergic Rhinitis
• Motion Sickness
• Urticaria
• Common Cold Symptoms

✔️ How does Avil (45.5mg/2ml) Injection work?

Pheniramine is an antihistamine and anticholinergic that is used to treat hay fever. It works by inhibiting the action of histamine. To do so the drug molecules bind with histamine H1 receptor proteins present in effector cells.

✔️ Side Effects of Avil (45.5mg/2ml) Injection

• Common: Sedation, which may decrease with tolerance. Hypersensitivity reactions.
• CNS: Lassitude, dizziness, tinnitus, inability to concentrate, incoordination, irritability, insomnia, tremors, agitation, convulsions (especially in children), restlessness, disorientation, hallucinations (especially in overdose).
• Gastrointestinal: Nausea, vomiting, diarrhea, colic, epigastric pain, anorexia, dry mouth, constipation.
• Genitourinary: Urinary retention.
• Cardiovascular: Palpitations, headache.
• Ocular: Blurred vision, increased intraocular pressure.
• Musculoskeletal: Muscular weakness.
• Hematological: Rare cases of blood dyscrasias, including agranulocytosis and hemolytic anemia.

✔️ Quick Suggestions:

• Inform your doctor if you have any other allergies including food allergies.
• Avoid consuming alcohol when taking the Nicophen 22.75mg Injection, as it may cause excessive sleepiness or drowsiness.
• Inform your doctor if you are taking any other medications, e.g., anti-depressants.
• Keep sipping water or have sugar-free gum to relieve dryness in the mouth.
• Avoid stepping outside during peak pollen season and protect yourself from dust and mites at home.

✔️ Indication of Avil (45.5mg/2ml) Injection

Avil is a competitive H1 histamine receptor antagonist. Like other alkylamine antihistamines, it also antagonizes muscarinic cholinergic receptors and has local anesthetic properties, although these effects are not achieved at therapeutic doses.

✔️ Pharmacology

Pheniramine, the active ingredient in Avil, competes with histamine for the H1 receptor, acting as an inverse agonist. This reduces itching, vasodilation, and capillary leakage, leading to less redness and edema. In the CNS, inverse agonism of the H1 receptor is responsible for sedation, a common effect of first-generation antihistamines like pheniramine.

✔️ Dosage & Administration of Avil (45.5mg/2ml) Injection

Injection Solution: For adults and young people aged 12 years or over, 1.0-2.0 ml IV/IM once or twice daily. For children, the dosage varies based on age and body weight.

For Travel Sickness: Take the first dose at least 30 minutes before traveling. Due to potential drowsiness, avoid driving or operating machinery after taking a dose.

Avil (45.5mg/2ml) Injection will be administered to you only by a doctor or a nurse into a vein as a slow intravenous injection or into a muscle (intramuscularly). To infants and children up to 12 years of age, the medicine will be given intramuscularly. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and general health condition.  

✔️ Interaction

• MAO Inhibitors: May prolong and intensify the anticholinergic effects of pheniramine.
• Alcohol & CNS Depressants: May enhance adverse CNS effects.
• Atropine & Related Drugs: May enhance the anticholinergic activity of pheniramine.

✔️ Contraindications

• Hypersensitivity to pheniramine or any ingredient in the formulation.
• Symptomatic prostatic hypertrophy.
• Patients receiving MAO-inhibitor therapy.
• Newborn and premature infants.

✔️ Pregnancy & Lactation

Pregnancy Category A: Use only if strictly indicated.

✔️ Precautions & Warnings

• May cause drowsiness; caution is advised for activities requiring concentration.
• Avoid alcohol and other CNS depressants.
• Potential for abuse due to CNS stimulating effects.
• Use with caution in patients with prostatic hypertrophy, narrow-angle glaucoma, asthma, or severe cardiovascular disease.
• May mask the signs of other conditions due to anti-emetic effects.
• Should not be taken on an empty stomach.

✔️ Storage:

Store in a cool, dry place protected from light. Keep out of reach of children. Use only as prescribed by a physician.