Cortan 20mg (50pcs Box)

Indications of Cortan 20

• Rheumatic Disorders include post-traumatic osteoarthritis, acute gouty arthritis, acute nonspecific tenosynovitis, psoriatic arthritis, rheumatoid arthritis, juvenile rheumatoid arthritis, ankylosing spondylitis, acute and subacute bursitis, and acute nonspecific tenosynovitis.
• Endocrine disorders include nonsuppurative thyroiditis, primary or secondary adrenocortical insufficiency, congenital adrenal hyperplasia, and hypercalcemia linked to cancer.
• Pemphigus, bullous dermatitis herpetiformis, severe erythema multiforme, exfoliative dermatitis, mycosis fungoides, and severe psoriasis are examples of dermatological conditions.
• Seasonal or persistent allergic rhinitis, bronchial asthma, contact dermatitis, atopic dermatitis, serum sickness, and adverse drug reactions are examples of allergic states.
• Symptomatic sarcoidosis, berylliosis, fulminating, and aspiration pneumonitis is respiratory diseases.
• Hematologic disorders include acquired (autoimmune) hemolytic anemia, erythroblastopenia, secondary thrombocytopenia, and idiopathic thrombocytopenic purpura (RBC anemia).
• Edematous States: To cause diuresis or remission of proteinuria in nephrotic syndrome, without uremia, whether it be of the idiopathic type or that caused by lupus erythematosus.
• Regional enteritis and ulcerative colitis are gastrointestinal disorders.
• Gastrointestinal Diseases: Ulcerative colitis, regional enteritis.

Pharmacology

Prednisolone is a synthetic adrenocortical drug that functions similarly to glucocorticoids. The Phospholipase A2 enzyme, which produces inflammatory mediators like leukotrienes, SRS-A, and prostaglandins, is inhibited by prednisolone. Prednisolone is quickly and completely absorbed from the GI tract after oral ingestion. Prednisolone has a half-life of 2 to 4 hours before it is excreted and is 70–90% protein-bound in the plasma. The liver is where it is primarily processed, and urine is where it is eliminated.

Dosage and Administration

Adult-

Allergic Conditions:

• Day 1: 10 mg PO before breakfast, 5 mg after lunch and after dinner, and 10 mg at bedtime.
• Day 2: 5 mg PO before breakfast, after lunch, and after dinner, and 10 mg at bedtime.
• Day 3: 5 mg PO before breakfast, after lunch, after dinner, and at bedtime.
• Day 4: 5 mg PO before breakfast, after lunch, and at bedtime.
• Day 5: 5 mg PO before breakfast and at bedtime.
• Day 6: 5 mg PO before breakfast.

Nephrotic Syndrome:

• Initial: 2 mg/kg/day (maximum 80 mg/day) in divided doses 3 to 4 times/day until urine is protein-free for 3 consecutive days (maximum: 28 days); followed by 1 to 1.5 mg/kg/dose given every other day for 4 weeks.
• Maintenance dose: 0.5 to 1 mg/kg/ dose given every other day for 3 to 6 months.

Anti-inflammatory: 

• 5 to 60 mg per day in divided doses 1 to 4 times/day.

Acute Asthma: 

• 40-60 mg/day PO in a single daily dose or divided q12 hr for 3-10 days.

Pediatric-

Asthma:

• 1 year: Acute: 10 mg orally every 12 hours. Maintenance: 10 mg orally every other day.
• 1 to 4 years: Acute: 20 mg orally every 12 hours. Maintenance: 20 mg orally every other day.
• 5 to 12 years: Acute: 30 mg orally every 12 hours. Maintenance: 30 mg orally every other day.
• 12 years: Acute: 40 mg orally every 12 hours. Maintenance: 40 mg orally every other day.

Anti-inflammatory: 

• 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Immunosuppression: 

• 0.05 to 2 mg/kg/day divided 1 to 4 times/day.

Interaction of Cortan 20

Aminoglutethimide, Antacids, Barbiturates, Carbamazepine, Griseofulvin, Mitotane, Phenylbutazone, Phenytoin, Primidone, and Rifampin all decrease the effectiveness of prednisolone. The amount of potassium in the blood is decreased by prednisolone. If hypokalemia occurs, digitalis may cause cardiac arrhythmias. Care must be taken when administering vaccinations.

Contraindications

Unless specific anti-infective therapy is used, systemic infections can occur. Intolerance to any ingredient Herpes simplex ocular because of potential perforation

Side Effects of Cortan 20

Increased hunger, indigestion, agitation, and restlessness are all common adverse effects. Darkening or lightening of skin color, dizziness or lightheadedness, flushing of the face or cheeks, hiccups, increased sweating, and the impression of spinning is less common or rare adverse effects.

Pregnancy & Lactation

This medicine is not recommended for use during pregnancy unless considered essential by your doctor. It should only be used if the expected benefit to the mother is greater than any possible risk to the fetus. Corticosteroids appear in breast milk and could suppress growth, interfere with endogenous corticosteroid production or cause other unwanted effects.

Precautions & Warnings

Vigilance is necessary for those who have diabetes, hypertension, psychological issues, osteoporosis, postmenopausal women, pregnancy, and chronic nephritis. Long-term Prednisolone use may result in Cushing's syndrome, hyperglycemia, muscle weakness, heightened susceptibility to infection, sluggish wound healing, and psychological disorders.

Storage Conditions

Store in a cool and dry place, protected from light. Keep out of the reach of the children.