Generic Name: Fexofenadine Hydrochloride 30mg Company Name: Opsonin Pharma Limited
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Indications
Fixal belongs to the class of medications known as antihistamines. It is used to treat allergies such as hay fever, conjunctivitis, and some skin reactions such as eczema, hives, and bite and sting reactions. Watery eyes, a runny nose, sneezing, and itching are also relieved. Fixal should be taken first thing in the morning on an empty stomach. The dose may differ depending on the reason you are taking it. Take it exactly as directed by your doctor.
Pharmacology
Fexofenadine Hydrochloride is an antihistamine that works by blocking peripheral H1 receptors. After oral administration, it is rapidly absorbed and reaches maximal plasma concentration in 2-3 hours. It doesn't appear to be able to pass through the blood-brain barrier.
Dosage & administration
Tablet
Adults and children over the age of 12 Seasonal Allergic Rhinitis:
Suspension
Children aged 2 to 11 years with Seasonal Allergic Rhinitis:
Interaction
When combined with Erythromycin or Ketoconazole, plasma concentrations of Fexofenadine increased. Fexofenadine had no effect on Erythromycin or Ketoconazole pharmacokinetics. Fexofenadine absorption is reduced by antacids containing aluminum and magnesium hydroxide. It is best to wait 2 hours between taking Fexofenadine and antacids containing aluminum
Contraindications
Fexofenadine is contraindicated in patients with a known hypersensitivity to Fexofenadine or any of its ingredients.
Side effects
In general, fexofenadine is well tolerated. Headache, fatigue, dizziness or drowsiness, and nausea are the most common side effects. Rashes, urticaria, pruritus, and hypersensitivity reactions like angioedema, dyspnea, chest tightness, flushing, and systemic anaphylaxis have been reported in rare cases.
Pregnancy and lactation
Fexofenadine is pregnancy category B2. There are no adequate and well-controlled studies on pregnant women exposed to Fexofenadine alone or through the administration of Terfenadine. Fexofenadine should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus. It is not known if Fexofenadine is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when Fexofenadine is administered to a nursing woman.
Precautions and Warning
Studies in the elderly, patients with hepatic impairment, and patients with cardiac disease exposed to Fexofenadine through administration of Terfenadine showed no statistically significant differences in pharmacokinetic parameters for Fexofenadine when compares to those pharmacokinetic parameters in healthy individuals. There is only limited data on the elderly and really or hepatically impaired patients. Fexofenadine should be administered with care in these special groups. Fexofenadine causes drowsiness less than other antihistamines; therefore caution should be advised during driving or operating potentially dangerous machinery.
Storage conditions
Store in a cool and dry place. Protect from light. Keep away from the reach of children.
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