Gludex IM/IV Injection

✔️ Uses of Gludex IM/IV injection

• Allergic conditions
• Severe allergic reactions
• Asthma
• Cancer
• Rheumatic disorder
• Skin disorders
• Eye disorders
• Nephrotic syndrome

✔️ How does Gludex IM/IV injection work?

Gludex IM/IV is a steroid that works by blocking the production of certain chemical messengers in the body that cause inflammation (redness and swelling) and allergies.

✔️ Side Effects of Gludex IM/IV injection

Various adverse reactions are associated with prolonged use, including endocrine/metabolic, fluid/electrolyte disturbances, musculoskeletal effects, gastrointestinal effects, dermatological effects, CNS effects, ophthalmic effects, and immunosuppressive effects.

✔️ Quick Suggestions:

• Do not use it more often or for longer than advised by your doctor.
• Dexamethasone Injection may affect various laboratory tests.
• Dexamethasone can make it harder for you to fight off infections. Notify your doctor if you have any signs of infection such as a fever or sore throat.

✔️ Indications

• Severe allergic conditions
• Collagen diseases
• Pulmonary disorders
• Blood disorders
• Rheumatic diseases
• Skin diseases
• Gastrointestinal disorders
• Oedema
• Eye disorders
• Neoplastic states
• Endocrine disorders
• Preoperative and postoperative support
• Treatment of COVID-19 in certain patients

✔️ Pharmacology

Dexamethasone is a synthetic glucocorticoid that decreases inflammation, inhibiting leukocyte migration and reducing capillary permeability. It suppresses the normal immune response.

✔️ Dosage & Administration of Gludex IM/IV injection

Given intravenously (IV), intramuscularly (IM), or locally. The dosage depends on the severity, usually 0.05-0.20 mg/kg for systemic therapy in adults.

✔️ Interaction

• Diuretics and/or cardiac glycosides.
• Antidiabetics.
• Non-steroidal anti-inflammatory drugs.
• Oral anticoagulants.
• Less effective with liver enzyme-inducing drugs.

✔️ Contraindications

• Gastric and duodenal ulcers.
• Systemic and ophthalmic fungal infections.
• Viral infections.
• Glaucoma.
• Hypersensitivity to corticosteroids.

✔️ Pregnancy & Lactation

Category C. Use during pregnancy only if benefits justify risks. Glucocorticoids appear in breast milk.

✔️ Precautions & Warnings

• Use the lowest possible dose.
• Caution in cardiovascular, endocrine, gastrointestinal, musculoskeletal, and neuropsychiatric conditions.
• Pediatric patients should be titrated to the lowest effective dose.

✔️ Storage Conditions

Below 30°C, protected from light. Do not freeze. Keep out of reach of children.