Histacin Syrup 100ml

✔️ Uses of Histacin Syrup 100ml

• Allergic Conditions

✔️ Overdose Effects:

• Overdose may lead to various symptoms, including:
  • CNS depression (sedation, apnea, cardiovascular collapse)
  • CNS stimulation (insomnia, hallucinations, tremors, convulsions)
  • Tinnitus (ringing in the ears)
  • Dizziness
  • Ataxia (loss of coordination)
  • Hypotension (low blood pressure)
• Children are more likely to experience stimulation and atropine-like signs and symptoms.

✔️ Side Effects of Histacin Syrup

• Generally well tolerated but may cause side effects, including:
  • Drowsiness
  • Dizziness
  • Headaches
  • Psychomotor impairment
  • Urine retention
  • Dry mouth
  • Blurred vision
  • Paradoxical stimulation (especially in children or at high doses)

✔️ Quick Suggestions:

• It is typically recommended for short-term use until your symptoms are cleared, and it should not be taken for longer than 7 days in a row.
• It may cause drowsiness, so it's important to avoid activities that require coordination and judgment, and alcohol should be avoided.

✔️ Indication

1. Urticaria (hives)
2. Sensitivity reactions
3. Angioneurotic edema (swelling under the skin)
4. Vasomotor rhinitis (runny or stuffy nose due to allergies)
5. Cough and common cold symptoms
6. Motion sickness
7. Other allergic conditions

✔️ Pharmacology

• Chlorpheniramine Maleate is an alkylamine antihistamine.
• It is a potent histamine H1-receptor blocker.
• It competitively inhibits the H1 receptor to relieve symptoms associated with allergies.

✔️ Dosage & Administration of Histacin Syrup

Adult Dose:

Oral (By Mouth) for Allergic Conditions:

• 4 mg every 4-6 hours.
• Maximum daily dose: 24 mg.

Parenteral (Injection) for Anaphylactic Shock (Emergency Treatment):

• 10-20 mg via intramuscular (IM), subcutaneous (SC), or slow intravenous (IV) injection over 1 minute.
• Maximum daily dose: 40 mg.

Child Dose:

Oral for Allergic Conditions:

• 1-2 years: 1 mg twice daily.
• 2-5 years: 1 mg every 4-6 hours.
• 6-12 years: 2 mg every 4-6 hours.
• Maximum daily dose:
  • For children aged 1-5 years: 6 mg.
  • For children aged 6-12 years: 12 mg.

Parenteral for Anaphylactic Shock (Emergency Treatment):

• Child: 87.5 micrograms (mcg) per kilogram (kg) subcutaneously (SC) four times daily.

Please keep in mind that these dosages are general recommendations and should be used as a reference. Always consult with a healthcare provider for the most accurate and appropriate dosing for your specific medical condition or the condition of the individual being treated.

✔️ Interaction

• Histacin (Chlorpheniramine) may interact with certain drugs, including pentobarbital sodium, calcium chloride, kanamycin sulfate, noradrenaline acid tartrate, and meglumine adipiodone.

✔️ Contraindications

Histacin Syrup 100ml is contraindicated in patients with:

• Hypersensitivity to chlorpheniramine maleate or any component.
• Narrow-angle glaucoma.
• Bladder neck obstruction.
• Symptomatic prostate hypertrophy.
• During acute asthmatic attacks.
• Stenosing peptic ulcer.
• Pyloroduodenal obstruction.
• Avoid use in premature and term newborns due to a possible association with Sudden Infant Death Syndrome (SIDS).

✔️ Pregnancy & Lactation

This drug should not be used in lactating mothers and during pregnancy, especially in the first trimester.

✔️ Precautions & Warnings

• Use with caution in patients with glaucoma and prostatic hypertrophy.
• Caution should be taken when driving vehicles or operating machinery during chlorpheniramine therapy.

✔️ Storage Conditions

• Store in a cool place (below 25°C), in a dry place protected from light.
• Keep out of the reach of children.