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Indications of Zeltas
Azelastine and Fluticasone Nasal Spray is used to treat the symptoms of seasonal allergic rhinitis in individuals aged 6 and above who require symptomatic relief from both Azelastine Hydrochloride and Fluticasone Propionate.
Pharmacology of Zeltas
In isolated tissues, azelastine hydrochloride has histamine H1-receptor antagonist action. Desmethylazelastine, the main metabolite, also has H1-receptor antagonist action. Fluticasone Propionate is an anti-inflammatory synthetic trifluorinated corticosteroid. Fluticasone Propionate's exact mechanism of action on allergic rhinitis symptoms is unknown. Multiple cell types (e.g., mast cells, eosinophils, neutrophils, macrophages, and lymphocytes) and mediators (e.g., histamine, eicosanoids, leukotrienes, and cytokines) involved in inflammation have been demonstrated to be affected by corticosteroids.
Dosage and Administration
Adult: The recommended dosage is one spray each nostril twice daily.
Paediatric: The safety and effectiveness of Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray has not been established for patients less than 6 years of age.
How to use the Nasal Spray-
Shake the bottle gently and remove the dust cover.
Hold the spray with your forefinger and middle finger on either side of the nozzle and your thumb underneath the bottle. Press down until a fine spray appears. If using for the first time or if you have not used it for a week or more, press the nasal applicator several times until a fine moist comes out from the container.
Gently blow the nose to clear the nostrils.
Close one nostril and carefully insert the nasal applicator into the open nostril. Tilt your head forward slightly and keep the spray upright. Breathe in through your nose and while breathing in, press the white-collar of nasal applicator firmly down once to release a spray.
Breathe out through your mouth.
Repeat the above steps in the same/another nostril for consecutive doses.
Cleaning: The nasal spray should be cleaned at least once a week. The procedures are as follows-
Remove the dust cover.
Gently pull off the nasal applicator.
Wash the applicator and dust cover in warm water.
Shake off the excess water and leave it to dry in a normal place. Avoid applying additional heat.
Gently push the applicator back on the top of the bottle and re-fix the dust cover.
Side Effects of Zeltas
Dysgeusia, epistaxis, and headache are the most prevalent side effects (>2% occurrence).
Pregnancy & Lactation
Category C pregnancy. In pregnant women, there have been no appropriate and well-controlled clinical trials using Azelastine Hydrochloride with Fluticasone Propionate Nasal Spray, Azelastine Hydrochloride alone, or Fluticasone Propionate alone. Only if the possible benefit to the mother outweighs the risk to the fetus should it be used in pregnant women.
Mothers who are breastfeeding: Azelastine Hydrochloride and Fluticasone Propionate Nasal Spray are not known to be excreted in human breast milk. Because many medications are secreted in human milk, care should be taken while giving medication to a nursing mother.
Precautions & Warnings
When using Azelastine and Fluticasone Nasal Spray, do not engage in hazardous occupations that need complete mental attention, such as driving or operating machinery. Concurrent use of this Nasal Spray with alcohol or other central nervous system (CNS) depressants should be avoided to avoid further decreased alertness and CNS impairment. In susceptible people, hypercorticism and adrenal suppression may occur at very high doses or at the standard dose. If these changes occur, the spray should be gradually phased off.
Therapeutic Class
Nasal Steroid Preparations
Storage Conditions
Keep the temperature below 25° C. Protected from the sun's rays. Refrigerated storage is not recommended. Keep out of children's reach.
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here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
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