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Embardia 40mcg/0.4ml Injection 1pc
Darbepoetin alfa is used in the treatment of anemia due to chronic kidney disease and anemia due to chemotherapy.
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✅ Description:
Safety Advices
Alcohol
UNSAFE
Avoid consumption of alcohol while taking Embardia Injection as it may increase dizziness and sleepiness.
Pregnancy
CONSULT YOUR DOCTOR
Embardia 40mcg/0.4ml Injection should be used with caution in pregnant women. If you are pregnant, think you may be pregnant, or are planning for a baby, consult your doctor before receiving it.
Breastfeeding
UNSAFE
Embardia 40mcg/0.4ml Injection is not recommended for use in breastfeeding women because it is not known if it is excreted in breast milk. Consult your doctor before receiving it.
Driving
CAUTION
Embardia 40mcg/0.4ml Injection should not affect the ability to drive or use machines.
Kidney
CONSULT YOUR DOCTOR
In patients with chronic kidney failure, your doctor will adjust the correct dose and duration of Embardia 40mcg/0.4ml Injection management depending on your age, body weight, and disease condition. Consult your doctor before receiving Embardia 40mcg/0.4ml Injection.
Liver
CONSULT YOUR DOCTOR
Embardia 40mcg/0.4ml Injection should be used with caution in patients with liver disease and hepatitis C. Consult your doctor before receiving Embardia 40mcg/0.4ml Injection.
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✔️ Composition of Embardia 40mcg/0.4ml Injection
DARBEPOETIN ALFA
✔️ Uses of Embardia 40mcg/0.4ml Injection
Treatment of Anaemia (in cancer and chronic kidney disease)
✔️ Side Effects of Embardia 40mcg/0.4ml Injection
- Hypertension
- Stroke
- Thromboembolic events
- Seizures
- Allergic reactions
- Pure Red Cell Aplasia (PRCA)
✔️ Quick Suggestions:
✔️ Indication of Embardia 40mcg/0.4ml Injection
Embardia (Darbepoetin alfa) is indicated for the treatment of anemia due to:
- Chronic Kidney Disease (CKD) in patients on dialysis and those not on dialysis.
- Anemia in patients receiving myelosuppressive chemotherapy, with at least two additional months of planned chemotherapy upon treatment initiation.
✔️ Pharmacology
Darbepoetin alfa is an erythropoiesis-stimulating agent (ESA). It is produced through recombinant DNA technology in Chinese Hamster Ovary (CHO) cells. It stimulates the production of red blood cells by acting on erythroid progenitor cells, similar to erythropoietin. Darbepoetin alfa differs from recombinant human erythropoietin by having five N-linked oligosaccharide chains (compared to three), leading to an extended half-life and prolonged activity.
✔️ Dosage & Administration of Embardia 40mcg/0.4ml Injection
Chronic Renal Failure (Adult Patients):
- Correction phase: Initial dose of 0.45 µg/kg once weekly via subcutaneous or intravenous route. For patients not on dialysis, 0.75 µg/kg can be given every two weeks or 1.5 µg/kg once monthly.
- Maintenance phase: This can be administered weekly, biweekly, or once monthly depending on the patient's hemoglobin level and dialysis status.
Chronic Renal Failure (Pediatric Patients ≥1 year):
- Correction phase: 0.45 µg/kg once weekly subcutaneously or intravenously, or 0.75 µg/kg every two weeks for non-dialysis patients.
- Maintenance phase: Same as adults, with possible higher doses for children under 6 years.
Chemotherapy-Induced Anemia (Adult Cancer Patients):
- Initial dose: 500 µg once every three weeks, or 2.25 µg/kg once weekly.
✔️ Administration Guidelines:
- Do not shake or freeze.
- Protect from light and inspect for particulates or discoloration before use.
- Do not dilute or mix with other drug solutions.
✔️ Drug Interactions:
- No formal drug interaction studies have been conducted with Darbepoetin alfa.
✔️ Contraindications
- Uncontrolled hypertension
- Pure Red Cell Aplasia (PRCA)
- History of serious allergic reactions to Darbepoetin alfa
✔️ Overdose Management:
- Overdose may result in elevated hemoglobin levels, which can be managed by stopping or reducing the dose and/or phlebotomy.
✔️ Pregnancy & Lactation
- Pregnancy Category C: Not enough data is available to determine potential harm to a fetus.
- It is not known whether Darbepoetin alfa is excreted in breast milk; use with caution in nursing mothers.
✔️ Precautions & Warnings
- Use with caution in patients with controlled hypertension, seizures, or a history of PRCA or allergies to Darbepoetin alfa.
- Monitor hemoglobin levels closely to avoid exceeding recommended levels.
✔️ Storage:
- Store at 2°C to 8°C.
- Do not freeze or shake.
- Protect from light, and store in the carton until use.
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