Eposis 2000 Injection - ePharma
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Home Medicines Anaemia Eposis 2000 IU Injection
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Eposis 2000 IU Injection

Type: Injection

Pack Size: 1s pack

Generic Name: Erythropoietin 2000 IU

Manufacturer/Distributor: Beacon Pharmaceuticals Ltd. 


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Discount Price: ৳ 967.26
MRP: ৳ 1029 6% Off

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✅ Description:

Indications

Erythropoietin is used to treat-

Anemia associated with chronic renal failure in both dialysis and non-dialysis patients.

Anemia in patients with non-myeloid malignancies who are experiencing anemia as a result of concurrent treatment.

To decrease the need for allogeneic blood transfusions, anemic patients (hemoglobin >10 to 13 g/dL) are scheduled for elective, noncardiac, nonvascular surgery.

In HIV-positive patients, anemia is linked to zidovudine medication.

 

Pharmacology

Erythropoietin (EPO) is a glycoprotein hormone that regulates the production of red blood cells in mammals. Recombinant human erythropoietin (r-HuEPO) is a pure glycoprotein made from mammalian cells that have had the human erythropoietin gene introduced into them.

 

Dosage

Treatment of anemia in chronic renal failure: Erythropoietin is administered to maintain hemoglobin concentration between 11 to 12 g/dl and hematocrit of 33-36 % in adults.

Starting dose:

Adult: Usually 50 to 100 lU/kg three times in a week (TIW) by IV or Subcutaneous route.

Pediatric: 50 lU/kg TIW by IV or Subcutaneous route.

Dose adjustment: Dose should be increased if hematocrit doses not increase by 5 to 6 points after 8 weeks therapy, and hematocrit is below suggested target range. Dose should be reduced when hematocrit approaches 36% or hematocrit increases >4 points in any 2-week period.

Maintenance dose: Maintenance dose must be individualized for each patient. In patients undergoing dialysis, the median maintenance dose is 75 lU/kg TIW, with a range from 12.5 to 525 lU/kg TIW as directed by the physician. In CRF patients not on dialysis, maintenance dose is 75 to 150 lU/kg/week.

Treatment of Anemia in Cancer Patients on Chemotherapy:

Starting dose:

Adult: 150 lU/kg TIW by Subcutaneous route or 40,000 IU Subcutaneous route weekly.

Pediatric: 25 to 300 lU/kg 3 to 7 times per week by Subcutaneous or IV route.

Dose adjustment: If the response is not satisfactory, the dose should be increased to 300 lU/kg TIW. If the hematocrit exceeds 40%, the dose should be withheld until the hematocrit falls to 36%.The dose should be reduced to 25% when treatment is resumed and titrated to maintain the desired hematocrit.

Surgery Patients: The recommended dose is 300 lU/kg/day subcutaneously for 10 days before surgery, on the day of surgery, and for 4 days after surgery. An alternate dose schedule is 600 lU/kg subcutaneously in once weekly dose (21, 14, and 7 days before surgery) plus a fourth dose on the day of surgery.

Zidovudine-treated HIV-infected Patients:
Starting dose

Adult: 100 lU/kg as an IV or Subcutaneous injection TIW for 8 weeks.

Pediatric: 50 to 400 lU/kg 2 to 3 times per week by Subcutaneous or IV route.

Dose adjustment: If the response is not satisfactory, the dose should be increased by 50-1001U/kg TIW. Response should be evaluated every 4 to 8 weeks thereafter and the dose adjusted accordingly by 50 to 100 lU/kg increments TIW.

Maintenance dose: The dose is titrated to maintain the hematocrit between 33-36%.

 

Administration

Do not shake. It is not necessary to shake Erythropoietin. Prolonged vigorous shaking may denature any glycoprotein, rendering it biologically inactive.

Parenteral drug products should be inspected visually for particulate matter and discoloration prior to administration.

Administer as an intravenous injection over 1-2 minutes. In patients on dialysis, the injection should follow the dialysis procedure. Slow injection over 5 minutes may be beneficial to those who experience flu-like symptoms.

Do not administer by intravenous infusion or in conjunction with other drug solutions.

For the subcutaneous route, a maximum of 1 ml_ at one injection site should generally not be exceeded. In the case of larger volumes, more than one site should be chosen for the injection.

 

Contraindications

Erythropoietin is contraindicated in patients with:

Uncontrolled hypertension

Known hypersensitivity to mammalian cell-derived products

A history of hypersensitivity to Erythropoietin or any component of the preparation.

 

Side Effects

General: Headache, dizziness, fever, malaise, arthralgia and occasionally hyperkalemia. Cardiovascular: Hypertension is the most common side effect, palpitations. Gastrointestinal: Nausea, vomiting, anorexia and diarrhea may occur occasionally. Allergic reactions.

 

Pregnancy & Lactation

Pregnancy Category C. Since there are no controlled studies of erythropoietin in pregnant women, and because animal reproduction studies are not always predictive of human responses, erythropoietin should be used during pregnancy only if clearly needed. It is not known whether this drug is excreted in human milk. Because many drugs are excreted in human milk, caution should be exercised when erythropoietin is administered to a nursing woman.

 

Precautions & Warnings

Erythropoietin should be used with caution in those patients with controlled hypertension, ischaemic vascular disease, history of seizures, or suspected allergy to the product.

Iron evaluation: Prior to and during Erythropoietin therapy, the patient's iron stores, including transferrin saturation and serum ferritin, should be evaluated. Transferrin saturation should be at least 20%, and ferritin should be at least 100 ng/ml. Virtually all patients will require supplemental Iron to increase or maintain transferrin saturation to levels that will adequately support erythropoiesis.

Storage Conditions

Erythropoietin should be stored at 2°C to 8°C. Protect from light. Do not freeze & avoid shaking.

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