Oroxat is indicated for the treatment of symptomatic anemia in adult patients associated with chronic kidney disease (CKD).
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Oroxat (Roxadustat) is the first-in-class orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It promotes erythropoiesis by:
Roxadustat inhibits HIF prolyl hydroxylase enzymes (HIF-PH), preventing the degradation of hypoxia-inducible factor (HIF) transcription factors. This increases HIF activity, leading to:
For Patients Not on Erythropoiesis-Stimulating Agents:
For Patients Switching from Erythropoiesis-Stimulating Agents:
Dose Adjustments:
Can be taken with or without food.
Phosphate Binders or Multivalent Cation-Containing Products:
Gemfibrozil or Probenecid:
Statins (Simvastatin, Rosuvastatin, Atorvastatin):
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At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.