Oroxat 70 | Roxadustat 70
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Oroxat 70

Generic: Roxadustat

Type: Tablet

Pack Size: 3pcs

Oroxat is indicated for the treatment of symptomatic anemia in adult patients associated with chronic kidney disease (CKD).

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✅ Description:

Oroxat (Roxadustat) is the first-in-class orally administered hypoxia-inducible factor prolyl hydroxylase inhibitor (HIF-PHI). It promotes erythropoiesis by:

  • Increasing endogenous erythropoietin (EPO) production.
  • Improving iron regulation.
  • Overcoming EPO-suppressive effects of inflammation on hemoglobin synthesis and red blood cell production.
  • Downregulating hepcidin to enhance iron availability.
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✔️ Mechanism of Action

Roxadustat inhibits HIF prolyl hydroxylase enzymes (HIF-PH), preventing the degradation of hypoxia-inducible factor (HIF) transcription factors. This increases HIF activity, leading to:

  • Enhanced production of EPO and EPO receptors.
  • Improved iron absorption, transport, and utilization.
  • Lowered hepcidin levels, increasing iron availability.
  • Coordinated erythropoiesis with hemoglobin (Hb) levels maintained near physiologic ranges, even in inflammatory conditions.
✔️ Benefits: Oroxat 70
  • Reduces cholesterol levels.
  • Enhances transferrin and releases stored iron.
✔️ Dosage & Administration of Oroxat 70
  • General Dosing: Taken orally three times per week, not on consecutive days.
  • Target Hemoglobin (Hb): 10–12 g/dL.

For Patients Not on Erythropoiesis-Stimulating Agents:

  • Adults:
    • Weighing <100 kg: 70 mg three times weekly.
    • Weighing ≥100 kg: 100 mg three times weekly.

For Patients Switching from Erythropoiesis-Stimulating Agents:

  • Adults: Starting dose: 70–100 mg three times weekly, adjusted as needed.

Dose Adjustments:

  • Increase or decrease the dose based on Hb levels.
  • Maintain adjusted doses for at least 4 weeks.
  • Suspend treatment if Hb rises >2 g/dL within 4 weeks.
  • Dose options range from 20 mg to 400 mg for CKD patients on dialysis.
✔️ Missed Dose: Oroxat 70
  • If ≥24 hours remain before the next dose, take the missed dose immediately.
  • If <24 hours remain, skip the missed dose.
  • Do not take two doses in one day.
✔️ Administration: Oroxat 70

Can be taken with or without food.

✔️ Common Adverse Reactions
  • Hypertension
  • Vascular access thrombosis
  • Diarrhea
  • Peripheral edema
  • Hyperkalemia
  • Nausea
✔️ Interaction

Phosphate Binders or Multivalent Cation-Containing Products:

  • Risk: Reduced absorption of Oroxat.
  • Recommendation: Take Oroxat at least 1 hour after these products.

Gemfibrozil or Probenecid:

  • Risk: Increased Oroxat levels (AUC ↑ 2.3-fold, Cmax ↑ 1.4-fold).
  • Recommendation: Adjust dosage based on Hb monitoring.

Statins (Simvastatin, Rosuvastatin, Atorvastatin):

  • Risk: Increased AUC and Cmax.
  • Recommendation: Adjust dosage accordingly.
✔️ Precautions & Warnings
  • Seizures: Use with caution in patients with a history of seizures.
  • Infections: Avoid administration in patients with serious infections.
  • Liver Disorders: Do not administer to patients with liver disease or severe hepatic impairment.
  • Pregnancy: Contraindicated in pregnant women.
  • Breastfeeding: Contraindicated during lactation.
  • Children: Not indicated for pediatric use.
✔️ Overdose:
  • Symptoms include transient tachycardia and excessive Hb increase. Treatment involves dose reduction or treatment interruption.
✔️ Storage:
  • Store below 30°C in a cool, dry place.
  • Protect from light and moisture.
  • Keep out of reach of children.
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Delivery typically takes 1-2 business days, depending on your location.

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Currently, ePharma only delivers within Bangladesh.

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We accept debit/credit cards, Bkash, Nagad, and cash on delivery.

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Check our pricing section for Oroxat 70 price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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