Ferric iron works by binding dietary phosphate in the gastrointestinal (GI) tract, forming ferric phosphate, which is insoluble and excreted in the stool. This process reduces phosphate absorption and lowers serum phosphorus levels. Ferric iron is converted to its ferrous form in the GI tract by ferric reductase and transported through enterocytes into the bloodstream. In the blood, ferric iron binds to the plasma protein transferrin, which facilitates its incorporation into hemoglobin.
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Safety and efficacy have not been established for pediatric or adolescent patients.
No specific data is available for Revocit overdose. In CKD patients, the maximum studied dose is 2,520 mg of ferric iron per day.
There is no sufficient data on the safety of Ferric Citrate in pregnant or breastfeeding women. Consult a healthcare provider before use.
Revocit may interfere with the absorption of certain oral drugs like doxycycline and ciprofloxacin. It is recommended to separate their administration times.
Do not use Ferric Citrate in patients with iron overload disorders such as hemochromatosis.
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