Etnol 50 | 1 Strip

✔️ Pharmacology

Atenolol is a β1-selective (cardioselective) beta-blocker with no partial agonist or membrane-stabilizing activity.

It primarily blocks cardiac β1-receptors, with minimal penetration of cell membranes due to high hydrophilicity.

Reduces heart rate, myocardial contractility, and cardiac output, lowering blood pressure and oxygen demand.

✔️ Side Effects

• Bradycardia, hypotension
• Fatigue, dizziness
• CNS: mental depression, disorientation, short-term memory loss
• Hematologic: agranulocytosis
• Allergic: fever, sore throat, laryngospasm
• GI: ischemic colitis, mesenteric thrombosis
• Skin: rash, dry eyes

✔️ Overdose Effects

• Symptoms: lethargy, respiratory depression, bradycardia, hypotension, bronchospasm, hypoglycemia, heart failure.
• Treatment: gastric lavage, activated charcoal, induced emesis; hemodialysis can remove the drug.
• Supportive care for cardiac and respiratory complications may be necessary.

✔️ Dosage & Administration

Hypertension:

• Initial: 50 mg once daily.
• If response inadequate: increase to 100 mg once daily.
• Max effect usually within 1–2 weeks; doses beyond 100 mg/day rarely add benefit.

Angina Pectoris:

• Start: 50 mg once daily.
• May increase to 100 mg, or 200 mg for optimal effect.
• Once-daily dosing provides 24-hour control when using higher doses.

Acute Myocardial Infarction:

Start IV: 5 mg over 5 minutes, followed by another 5 mg after 10 minutes.

Then initiate oral Atenolol 50 mg, followed by 50 mg 12 hours later.

Maintenance: 100 mg once daily or 50 mg twice daily for 6–9 days or until hospital discharge.

Discontinue if bradycardia, hypotension, or other adverse effects occur.

রেজিস্টার্ড চিকিৎসকের পরামর্শ মোতাবেক ঔষধ সেবন করুন।

✔️ Contraindications:

• Sinus bradycardia
• Heart block > first degree
• Cardiogenic shock
• Overt cardiac failure
• Hypersensitivity to atenolol or its components

✔️ Precautions & Warnings

Use with caution in patients with renal impairment, elderly patients, or peripheral arterial disease.

Dose adjustments required in renal dysfunction:

CrCl 15–35 mL/min/1.73 m²: max 50 mg/day

CrCl <15 mL/min/1.73 m²: max 25 mg/day

Monitor elderly patients closely; start at low doses due to decreased renal, hepatic, or cardiac function.

May aggravate peripheral arterial circulatory disorders.

✔️ Pregnancy & Lactation

Pregnancy Category D — use with caution.

Lactation: may cause bradycardia in breastfed infants; avoid in premature or renal-impaired infants.

✔️ Storage:

• Store below 30°C, in a cool, dry place, away from light and moisture.
• Keep out of reach of children.
• Use only as prescribed by a registered physician