Denixil 0.5 | Clonazepam | Price in Bangladesh | ePharma
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Denixil 0.5mg Tablet 10pcs

Generic: Clonazepam

Type: Tablet

Pack Size: 10 Pcs

Denixil 0.5mg Tablet is used in the treatment of anxiety disorder and epilepsy/seizures.


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Discount Price: ৳ 62.4
MRP: ৳ 65 4% Off

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✅ Description:

Clonazepam is used to treat or prevent seizures, panic attacks, and sleep disorders by stimulating the release of gamma-amino-butyric acid (GABA), which controls electrical disturbances in the brain. Common side effects include fatigue, dizziness, depression, and memory impairment, which usually do not need medical attention. However, seek medical advice if you experience breathing difficulty, excessive drowsiness, hallucinations, behavioral changes, or suicidal thoughts.

Clonazepam can be taken with or without food but should be taken exactly as prescribed due to its addiction risk. It is not recommended for patients with kidney or liver problems and may not be safe during pregnancy or breastfeeding unless the benefits outweigh the risks. Inform your doctor if you are pregnant or breastfeeding.

Due to dizziness as a side effect, avoid driving or activities requiring concentration. Do not consume alcohol while taking Clonazepam, as it may increase dizziness and drowsiness.

Safety Advices


Alcohol
UNSAFE

Avoid consuming alcohol as it may increase dizziness and drowsiness.


Pregnancy
UNSAFE

Denixil 0.5mg Tablet is not recommended for use in pregnancy as it may negatively affect the growth of your unborn baby. Hence, inform your doctor if you are pregnant or planning pregnancy before taking this medicine. He/she may prescribe this medicine only if the benefits outweigh the risks.


Breastfeeding
UNSAFE

Clonazepam is not recommended for use in breastfeeding women as this medicine can pass into the breast milk in a small amount. Take this medicine while breastfeeding only if your doctor prescribes it.


Driving
UNSAFE

Do not drive or do anything that requires mental focus until you know how Denixil 0.5mg Tablet affects you.


Kidney
CONSULT YOUR DOCTOR

Denixil 0.5mg Tablet should be used with caution in patients with kidney disease. A dose adjustment of Denixil 0.5 may be needed. Please consult your doctor. The use of Denixil 0.5mg Tablet can cause excessive sleepiness in patients with end-stage kidney disease.


Liver
CONSULT YOUR DOCTOR

Denixil 0.5mg Tablet should be used with caution in patients with liver disease. A dose adjustment of Denixil 0.5 may be needed. Please consult your doctor.

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✔️ Uses of Denixil 0.5mg Tablet
  • Seizure disorder
  • Panic attacks
  • Sleep disorders
✔️ Side Effects of Denixil 0.5mg Tablet

Common side effects include CNS depression, with drowsiness occurring in about 50% of patients, and ataxia in about 30%. Behavioral problems in about 25% of patients. Other side effects: abnormal eye movements, aphonia, coma, tremor, vertigo, confusion, depression, amnesia, hallucinations, hysteria, increased libido, insomnia, psychosis, and palpitations.

✔️ How does Denixil 0.5mg Tablet work?

Clonazepam works by stimulating the release of a chemical [gamma-amino-butyric-acid (GABA)] that calms the abnormal electrical activity in the brain.

✔️ Quick Suggestions:
  • Take Clonazepam with/without food, and take the medicine with a sufficient amount of water.
  • Do not break, crush, or chew the tablet/capsules. It should be taken exactly as instructed by your doctor.
  • Given that the medicine has habit-forming tendencies, taking the right quantity for the right duration is critical.
  • This medicine may cause dizziness, and avoid doing activities (such as driving or operating heavy machines) that require high mental alertness. Never discontinue usage without consulting your doctor.
✔️ Indication of Denixil 0.5mg Tablet
  • Panic Disorder: Treatment of panic disorder, with or without agoraphobia. Panic disorder is characterized by unexpected panic attacks and concern about having additional attacks or worry about the consequences.
  • Seizure Disorders: Alone or as an adjunct in treating Lennox-Gastaut Syndrome (petit mal variant), akinetic, and myoclonic seizures. It may be indicated for patients with absence seizures (petit mal) who have not responded to succinimides.

The effectiveness of Denixil for long-term use (over 9 weeks) has not been systematically studied. Physicians should periodically reevaluate the drug's long-term usefulness for individual patients.

✔️ Pharmacology

Clonazepam, a benzodiazepine, has anticonvulsive, sedative, muscle-relaxing, and anxiolytic properties. These effects are mediated through the enhancement of GABAergic neurotransmission at inhibitory synapses, increasing GABA receptor affinity for the neurotransmitter, and enhancing chloride ion flux. Clonazepam also affects serotonin and has been shown to suppress various types of paroxysmal activity, making it beneficial for both generalized and focal epilepsies.

✔️ Dosage & Administration of Denixil 0.5mg Tablet

Oral Administration:

  • Adults:
    • Seizure disorders: The initial dose should not exceed 1.5 mg/day in three doses. Increase by 0.5 to 1 mg every 3 days until control or side effects preclude further increase. The maximum daily dose is 20 mg.
    • Panic disorder: Initial dose is 0.25 mg in two divided doses, increasing to 1 mg/day after 3 days.
  • Pediatric Patients:
    • For infants and children (up to 10 years or 30 kg), the initial dose is 0.01-0.03 mg/kg/day, not exceeding 0.05 mg/kg/day, in two or three divided doses.
✔️ Interaction

Denixil does not alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. The effect on other drugs is not investigated.

✔️ Contraindications
  • Hypersensitivity to benzodiazepines
  • Significant liver disease
  • Contraindicated in acute narrow-angle glaucoma, but can be used with open-angle glaucoma receiving appropriate therapy.
✔️ Pregnancy & Lactation
  • Pregnancy: Clonazepam may cause congenital malformations. It should be administered only if the benefits outweigh the risks. High doses during the last trimester of labor can cause irregular fetal heartbeat, hypothermia, hypotonia, mild respiratory depression, and poor feeding in the neonate. Abrupt discontinuation can exacerbate epilepsy.
  • Nursing Mothers: Clonazepam passes into maternal milk in small amounts. If necessary, breastfeeding should be discontinued.
✔️ Precautions & Warnings
  • Coexisting seizure disorders may require additional anticonvulsants.
  • Valproic acid with Denixil may cause absence status.
  • For pediatric patients, monitor for increased salivation and bronchial secretion.
  • Elderly patients are more sensitive to benzodiazepine effects.
  • Renal impairment does not require dose adjustment.
  • Use caution with hepatic impairment due to altered drug clearance.
✔️ Storage Conditions:

Store in a dry place away from light and heat, and keep out of reach of children.

Frequently Asked Questions (FAQ)

Symptoms: Drowsiness, ataxia, dysarthria, nystagmus, cardiorespiratory depression, coma. Treatment: Supportive care, activated charcoal if within 1-2 hours of ingestion. Severe CNS depression may require flumazenil, a benzodiazepine antagonist, with careful monitoring due to short half-life and seizure risk.

No

The effect of Clonazepam can be observed within 30 to 60 minutes after taking it.

The effect of Clonazepam lasts for an average duration of 6 to 8 hours in adults. This duration can increase up to 12 hours in children.

If both these medications are used together the side effects may increase. The side effects might include drowsiness, confusion, weakness, breathing trouble, etc.
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Check our pricing section for Denixil 0.5mg Tablet 10pcs price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

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