Epitra (Clonazepam) is indicated for the treatment of panic disorder, with or without agoraphobia. It is also used alone or as an adjunct in the treatment of Lennox-Gastaut Syndrome (petit mal variant), akinetic and myoclonic seizures. Additionally, it may be prescribed for patients with absence seizures (petit mal) who have not responded to succinimides.
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Clonazepam
During therapy, your doctor may conduct blood tests to assess liver function.
Always consult your doctor before taking Epitra 0.5mg Tablet, especially if you have any underlying medical conditions or concerns about potential side effects.
It's advised to abstain from alcohol consumption while on Epitra 0.5mg Tablet. Alcohol intake can trigger seizures, worsen side effects, and lead to severe sedation.
Epitra 0.5mg Tablet is generally not recommended during pregnancy unless deemed necessary by a doctor. Consult your healthcare provider before use.
Avoid using Epitra 0.5mg Tablet while breastfeeding as it may pass into breast milk, potentially causing drowsiness and feeding difficulties. Consult your doctor before use.
Epitra 0.5mg Tablet may induce drowsiness or sleepiness, impairing your ability to drive or operate machinery. Avoid these activities while taking this medication.
Use caution when taking Epitra 0.5mg Tablet in patients with severe kidney disease. Consult your doctor before use.
Epitra 0.5mg Tablet is not recommended for patients with severe liver disease. Use with caution in those with mild to moderate liver issues. Consult your doctor before use.
Used to treat
Epitra 0.5mg Tablet belongs to benzodiazepines which work by enhancing the activity of GABA (gamma-aminobutyric acid) an inhibitory neurotransmitter (a chemical in the brain).
Serious Side Effects:
Common Side Effects:
Clonazepam, the active ingredient in Epitra, exhibits properties common to benzodiazepines, including anticonvulsive, sedative, muscle relaxing, and anxiolytic effects. It enhances GABAergic neurotransmission at inhibitory synapses, resulting in increased action of released GABA on postsynaptic transmembrane chloride ion flux. Clonazepam also affects serotonin and suppresses various types of paroxysmal activity, making it beneficial in generalized and focal epilepsies.
For adults with seizure disorders, the initial dose should not exceed 1.5 mg/day, divided into three doses. The dosage may be increased gradually until seizures are controlled, with a maximum daily dose of 20 mg. For panic disorder, the initial dose is 0.25 mg twice daily, with a target dose for most patients of 1 mg/day. Pediatric dosing should be individualized based on age and weight.
Overdose may cause drowsiness, ataxia, dysarthria, and respiratory depression. Supportive measures should be instituted as needed, and activated charcoal may be used to prevent further absorption. Flumazenil, a benzodiazepine antagonist, may be considered in severe cases.
Epitra does not significantly alter the pharmacokinetics of certain drugs like phenytoin, carbamazepine, or phenobarbital. However, its effect on the metabolism of other drugs has not been fully investigated.
Epitra should not be used in patients with a history of hypersensitivity to benzodiazepines or with clinical or biochemical evidence of significant liver disease. It is contraindicated in acute narrow-angle glaucoma.
Clonazepam may cause congenital malformations and should be used during pregnancy only if the benefits outweigh the risks. It passes into breast milk in small amounts, so breastfeeding is not recommended during treatment.
Epitra may increase the incidence of generalized tonic-clonic seizures in patients with multiple seizure disorders. Caution is advised when using it concurrently with valproic acid. In pediatric patients, increased salivation and bronchial secretions may occur. In geriatric patients, benzodiazepine effects may be greater due to age-related changes.
Store Epitra in a dry place away from light and heat, and keep it out of reach of children.
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