Leptic 2mg Tablet 10pcs

Uses of Leptic 2

How does Leptic 2 work?

It works by increasing the action of a chemical messenger (GABA) which suppresses the abnormal and excessive activity of the nerve cells in the brain.

Side Effects of Leptic 2

Common side effects include CNS depression, drowsiness (50% of cases), and ataxia (30%). Behavioral problems have been observed in 25% of patients. Other side effects include tremors, confusion, depression, hallucinations, and psychosis.

Overdose may cause drowsiness, ataxia, coma, and respiratory depression. Monitoring and supportive treatment are necessary, and flumazenil may be used as an antidote in severe cases.

Quick Suggestions:

• Avoid consuming alcohol as it may increase dizziness and drowsiness.
• Inform your doctor if you are pregnant, planning to conceive or breastfeeding.
• Inform your doctor if you experience worsen anxiety, depression angry, or violent behavior and mania while taking this medicine.
• It may cause dizziness. Do not drive or do anything that requires mental focus until you know how this medicine affects you.
• Do not stop taking medication suddenly without talking to your doctor as that may lead to nausea, anxiety, agitation, flu-like symptoms, sweating, tremor, and confusion.

Indication of Leptic 2

• Panic disorder: Characterized by unexpected panic attacks and associated concerns or worries.
• Seizure disorders: Used alone or in conjunction with other treatments for specific types of seizures, particularly when other anticonvulsants are ineffective.

Pharmacology

Clonazepam enhances GABAergic neurotransmission at inhibitory synapses, thereby increasing GABA’s effect on chloride ion flux at postsynaptic receptors. This leads to the anticonvulsant and sedative effects of the drug. It has also shown effects on serotonin and can suppress various types of paroxysmal EEG activity, making it useful in generalized and focal epilepsies.

Dosage & Administration of Leptic 2

Oral:

• For seizure disorders in adults, the initial dose is 1.5 mg/day, divided into three doses, and gradually increased as needed. Max daily dose: 20 mg.
• For panic disorder, the starting dose is 0.25 mg twice daily, increasing to a target of 1 mg/day.
• Pediatric patients' starting dose ranges from 0.01-0.03 mg/kg/day.

Interaction

Leptic does not alter the pharmacokinetics of phenytoin, carbamazepine, or phenobarbital. Its effect on the metabolism of other drugs remains unstudied.

Contraindications

• Hypersensitivity to benzodiazepines.
• Significant liver disease.
• Acute narrow-angle glaucoma (it can be used in open-angle glaucoma with appropriate therapy).

Pregnancy & Lactation

• Pregnancy: There is evidence suggesting the potential for teratogenic effects, though other factors (e.g., genetic predispositions) may also contribute. Use during pregnancy should only be considered if the benefits outweigh the risks.
• Lactation: Mothers undergoing treatment with clonazepam should not breastfeed.

Precautions & Warnings

• Caution in patients with multiple seizure types, as Leptic may precipitate tonic-clonic seizures.
• May increase saliva production and bronchial secretions in infants and young children.
• Elderly patients may experience enhanced benzodiazepine effects, such as sedation and cognitive impairment.
• Use cautiously in renal impairment (no dosage adjustment needed) and hepatic impairment (may affect clearance).

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