Pase 2mg Tablet 15pcs

✔️ Dosage & Administration

• Adults with Seizures: The starting dose should not exceed 1.5 mg per day, divided into three doses. Dosage may be gradually increased by 0.5 to 1 mg every three days until seizures are controlled or side effects limit further increments. The maximum daily dose is 20 mg.
• Adults with Panic Disorder: The initial dose is 0.25 mg per day, divided into two doses. After three days, the dosage may be increased to the target dose of 1 mg per day.
• Children (up to 10 years old or weighing ≤30 kg): To minimize drowsiness, the initial dose should be between 0.01 and 0.03 mg/kg per day, not exceeding 0.05 mg/kg per day, administered in two or three divided doses.
• Pediatric Use: Pase may increase saliva and bronchial secretions in infants and young children, necessitating careful airway management.
• Elderly Patients: The effects of benzodiazepines may be more pronounced in older individuals, possibly due to age-related changes in drug interactions and organ function.
• Renal Impairment: Pase’s pharmacokinetics remain unchanged in renal impairment, so no dosage adjustments are necessary.
• Hepatic Impairment: Liver disease can affect the metabolism of Pase, potentially increasing the amount of free (active) drugs in circulation.

✔️ Overdose Management

Symptoms: Overdosing on Pase may cause drowsiness, ataxia, slurred speech, and involuntary eye movements (nystagmus). Severe overdose may lead to loss of reflexes, respiratory depression, hypotension, coma, or cardiac complications. While rarely fatal when taken alone, overdose combined with other CNS depressants (including alcohol) can be life-threatening.

Treatment:

• Monitor vital signs and provide supportive care.
• If ingestion occurred within the past 1–2 hours, activated charcoal may help limit absorption. In drowsy patients, airway protection is necessary before using charcoal.
• Gastric lavage may be considered in cases of mixed overdose but is not routine.
• If CNS depression is severe, the benzodiazepine antagonist flumazenil may be used under close supervision. However, caution is required if the patient has also ingested drugs that lower the seizure threshold (e.g., tricyclic antidepressants).

✔️

Side Effects
Common side effects are related to central nervous system (CNS) depression. During seizure treatment, drowsiness occurs in about 50% of patients, and ataxia in around 30%, though these effects may lessen over time. Behavioral changes have been reported in approximately 25% of cases. Other possible adverse effects include:

• Abnormal eye movements
• Speech difficulties (aphonia)
• Confusion, tremors, vertigo
• Depression, hallucinations, amnesia
• Increased or decreased libido
• Insomnia, psychosis, heart palpitations
• In rare cases, coma

✔️ Interaction

Pase does not significantly impact the metabolism of phenytoin, carbamazepine, or phenobarbital. However, its effects on other drugs have not been fully investigated.

✔️ Contraindications

Pase should not be used in individuals with known hypersensitivity to benzodiazepines or those with significant liver disease. While it may be used in patients with open-angle glaucoma receiving appropriate treatment, it is contraindicated in cases of acute narrow-angle glaucoma.

✔️ Pregnancy & Lactation

• Pregnancy: Preclinical studies suggest clonazepam may pose a risk of congenital malformations. Epidemiological data indicate anticonvulsants may have teratogenic effects, but it is difficult to determine whether the defects result from the medication, genetic factors, or the epileptic condition itself. Pase should only be used during pregnancy if the potential benefits outweigh the risks. High doses administered in the last trimester or during labor may cause irregular fetal heart rates, hypothermia, hypotonia, respiratory issues, and poor feeding in newborns. Both pregnancy and abrupt discontinuation of Pase can worsen epilepsy.
• Lactation: Clonazepam is excreted in breast milk in small amounts. Nursing mothers should avoid breastfeeding while on Pase. If necessary, breastfeeding must be discontinued.

✔️ Precautions & Warnings

• In patients with multiple seizure types, Pase may increase the incidence of generalized tonic-clonic seizures, requiring dose adjustments or additional anticonvulsants.
• Combined use with valproic acid may lead to the absence of status epilepticus.

✔️ Storage:

Store in a dry place, away from heat and light. Keep out of reach of children.