Arthanib 5mg Tablet | Medicine
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Arthanib 5mg Tablet

Generic: Tofacitinib

Type: Tablet

Pack Size: 10pcs

Arthanib 5mg Tablet is used for the treatment of rheumatoid arthritis in adults.


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Discount Price: ৳ 456
MRP: ৳ 480 5% Off

⪼ Save  ৳: 24  in this Product


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✅ Description:

  • Tofacitinib is used alone or in combination with other medicines to reduce signs and symptoms of moderate to severely active rheumatoid arthritis in adult patients.
  • Specifically indicated for those who have had an inadequate response to methotrexate.
  • Tofacitinib is used in the management of psoriatic arthritis in adult patients.
  • Administered when there has been an insufficient response to methotrexate or other disease-modifying antirheumatic drugs (DMARDs).
  • Tofacitinib is employed in the treatment of ulcerative colitis in adult patients.
  • Indicated for those with moderately to severely active ulcerative colitis.
  • Tofacitinib can be taken with or without food.
  • Adhere to the prescribed dosage and do not exceed the recommended amount.
  • Do not take Tofacitinib in larger or smaller amounts than advised by your healthcare provider.
  • Report any undesirable effects or side effects to your doctor promptly.
  • Do not discontinue the medication without consulting your doctor.

Safety Advices


Alcohol
UNSAFE

Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.


Pregnancy
SAFE IF PRESCRIBED

Arthanib 5mg Tablet is not recommended for pregnant women unless the doctor deems the benefits greater than the risks.


Breastfeeding
SAFE

Arthanib 5mg Tablet is not recommended for breastfeeding women unless the doctor deems the benefits greater than the risks.


Driving
SAFE

Arthanib 5mg Tablet does not affect your ability to drive or use machines.


Kidney
CAUTION

Arthanib 5mg Tablet should be taken with caution in patients with kidney disease. The dose will be adjusted by your doctor Consult your doctor before taking it


Liver
CAUTION

Arthanib 5mg Tablet is not recommended in patients with severe liver problems such as cirrhosis (scarring of the liver). It should be used with caution in patients having other liver diseases such as hepatitis B or hepatitis C. Dose will be adjusted by your doctor. Consult your doctor before taking it.

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✔️ Composition of Arthanib 5mg Tablet

Tofacitinib

✔️ How does Arthanib 5mg Tablet work?

Arthanib is a Janus kinase inhibitor that blocks the action of the enzyme Janus kinase. This inhibition reduces inflammation and joint damage in rheumatoid arthritis.

✔️ Side Effects of Arthanib 5mg Tablet

Common Side Effects:

  • Throat and nose infections, nausea, viral infections.
  • Cold sores, feeling sick, symptoms of a cold (stuffy nose, sneezing, sore throat).

Serious Side Effects (Seek Urgent Medical Attention):

  • Blood clots, tears in the stomach or intestine wall.
✔️ Quick Suggestions:
  • It may take 3 to 6 months to feel the maximum effect of this medication.
  • Regular blood tests may be conducted to monitor liver function, kidney function, blood counts, or cholesterol levels.
  • Tofacitinib can make it a bit harder for people to fight off infections.
  • Inform your doctor if you have symptoms of an infection such as fever, chills, cough, and muscle aches.
  • A TB (tuberculosis) skin test and a chest X-ray may be done before starting treatment with this medication.
✔️ Indications:
  • Used to treat moderate to severe rheumatoid arthritis.
  • Reduces pain, tenderness, and swelling in joints by decreasing inflammation.
  • Slows the progression of bone and joint damage.
✔️ Pharmacology

Rheumatoid arthritis, an autoimmune disease, is characterized by the dysregulation of pro-inflammatory cytokines such as IL7, IL15, IL21, IL6, IFN-alpha, and IFN-beta. These cytokines signal through the Janus kinase (JAK) pathway, leading to tissue inflammation and joint damage by stimulating the recruitment and activation of immune cells.

Arthanib 5 mg, as a Partial and Reversible JAK Inhibitor:

  • Arthanib 5 mg is a partial and reversible Janus kinase (JAK) inhibitor.
  • It acts by preventing the body from responding to cytokine signals.
  • Inhibiting JAKs, Arthanib 5 mg hinders the phosphorylation and activation of STATs (signal transducers and activators of transcription).

Role of JAK-STAT Signaling Pathway:

  • The JAK-STAT signaling pathway is crucial in regulating the transcription of cells involved in hematopoiesis and immune cell function.
  • By inhibiting this pathway, Arthanib 5 mg decreases the inflammatory response, playing a therapeutic role in rheumatoid arthritis.

Other Pathways and Efficacy:

  • Although the primary mode of action is the inhibition of the JAK-STAT pathway, evidence suggests that Arthanib 5 mg may also achieve efficacy through alternative pathways.
  • This multifaceted action may contribute to the drug's effectiveness in managing rheumatoid arthritis.

In summary, Arthanib 5 mg's pharmacological action involves inhibiting the JAK-STAT signaling pathway, thereby reducing the inflammatory response associated with rheumatoid arthritis. The drug's partial and reversible JAK inhibition may also impact other pathways, enhancing its therapeutic effects.

✔️ Dosage & Administration:

Adult Dose for Rheumatoid Arthritis:

  • Indication: Second-line treatment for moderate-to-severe active rheumatoid arthritis in patients with an inadequate response or intolerance to methotrexate.
  • Usage: May be used as monotherapy or in combination with methotrexate or other nonbiologic DMARDs.
  • Recommended Dose: 5 mg twice daily.

Dosage Adjustment for Hepatic Impairment:

  • Mild Hepatic Impairment: No dosage adjustment is required.
  • Moderate Hepatic Impairment: Not to exceed 5 mg once daily.
  • Severe Hepatic Impairment: Not recommended.

Child Dose:

  • Safety and efficacy not established for children.

Dosage Adjustment for Renal Impairment:

  • Mild Renal Impairment: No dosage adjustment is required.
  • Moderate-to-severe Renal Impairment: Not to exceed 5 mg once daily.

Arthanib may be taken with or without food, but it is advised to take it at a fixed time each day. Swallow the tablet whole, without chewing or breaking.

✔️ Interaction

Antibiotics:

  • Rifampicin (used in treating bacterial infections)
  • Interaction Alert: Potential interactions with rifampicin. Discuss with your doctor to adjust the medication regimen accordingly.

Antifungals:

  • Fluconazole, ketoconazole (used to treat fungal infections)
  • Interaction Alert: Caution is advised due to potential interactions. Your doctor may need to monitor and adjust the doses appropriately.

Immunosuppressive Medications:

  • Azathioprine, mercaptopurine, ciclosporin, tacrolimus (medicines that depress the immune system)
  • Interaction Alert: Arthanib 5mg Tablet, being an immunosuppressant, may have additive effects when combined with these medications. Close monitoring is crucial.

Corticosteroids:

  • Prednisone (used in treating pain and inflammation)
  • Interaction Alert: Combined use with corticosteroids might potentiate immunosuppressive effects. Your doctor will determine the appropriate dosage and monitor for potential side effects.

Before taking Arthanib 5mg Tablet, it is essential to inform your physician about any ongoing medications, as interactions can occur.

✔️ Contraindications

Hypersensitivity to the active substance or any of the excipients.

✔️ Pregnancy & Lactation

Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Arthanib 5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether Arthanib 5 mg is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Arthanib 5 mg, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug for the mother

✔️ Precautions & Warnings
  • Blood tests may be required before initiation.
  • Avoid if there is any ongoing infection.
  • Discuss with the doctor before starting if there's a history of tuberculosis, shingles, kidney or liver disease, hepatitis B or C, or blood clots.
  • Not suitable for children under 18, pregnant, or breastfeeding women unless the benefits outweigh the risks.
  • Increases susceptibility to infections; avoid contact with individuals having contagious diseases (chickenpox, measles, flu).
✔️ Storage Conditions

Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.

Frequently Asked Questions (FAQ)

If you forget a dose, do not take a double dose. Continue as usual until the next scheduled dose and meal. Consult your doctor for advice.

Arthanib 5mg Tablet should be used with caution in patients aged 65 and older due to an increased risk of infections, heart attacks, and certain cancers. Consult your doctor before taking it.

Tofacitinib usually takes about 2 to 8 weeks to start feeling better, and it can take 3 to 6 months to feel the maximum effect.

Tofacitinib is approved for moderate to severe rheumatoid arthritis. It can be used alone or with other medicines like methotrexate. It may also be used earlier in treatment if the person does not respond well to prescribed drugs.

Tofacitinib may increase the risk of certain cancers (lymphoma and skin cancers) by affecting the immune system. Inform your doctor if you ever had or have any type of cancer.

No, Arthanib 5mg Tablet does not have weight gain or weight loss as common side effect. However, if you think you are experiencing changes in weight, talk to your doctor.
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Check our pricing section for Arthanib 5mg Tablet price in Bangladesh. After Submitting Order, You will receive a phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

Disclaimer:
ePharma sole intention is to ensure that its consumers get proper information as musch as possible. Although we do not guarantee the accuracy and the completeness of the information that provided and here information is for informational purposes only. The information contained herein should NOT be used as a substitute for the advice of a qualified physician. This may not cover everything about particular health conditions, lab tests, medicines, all possible side effects, drug interactions, warnings, alerts, etc. Please consult your healthcare professional and discuss all your queries related to any disease or medicine. We intend to support, not replace, the doctor-patient relationship.

Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing, Products and Service offerings for reasons including, but not limited to, changing market conditions, Product discontinuation, Product unavailability, manufacturer price changes, supplier price changes and errors in advertisements. All orders are subject to Product availability and the availability of Personnel to perform the Services. Therefore, Seller cannot guarantee that it will be able to fulfill Customer’s orders. If Services are being performed on a time and materials basis, any estimates provided by Seller are for planning purposes only.

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