Arthanib 5mg Tablet is used for the treatment of rheumatoid arthritis in adults.
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Interaction with alcohol is unknown. It is advisable to consult your doctor before consumption.
Arthanib 5mg Tablet is not recommended for pregnant women unless the doctor deems the benefits greater than the risks.
Arthanib 5mg Tablet is not recommended for breastfeeding women unless the doctor deems the benefits greater than the risks.
Arthanib 5mg Tablet does not affect your ability to drive or use machines.
Arthanib 5mg Tablet should be taken with caution in patients with kidney disease. The dose will be adjusted by your doctor Consult your doctor before taking it
Arthanib 5mg Tablet is not recommended in patients with severe liver problems such as cirrhosis (scarring of the liver). It should be used with caution in patients having other liver diseases such as hepatitis B or hepatitis C. Dose will be adjusted by your doctor. Consult your doctor before taking it.
Tofacitinib
Arthanib is a Janus kinase inhibitor that blocks the action of the enzyme Janus kinase. This inhibition reduces inflammation and joint damage in rheumatoid arthritis.
Common Side Effects:
Serious Side Effects (Seek Urgent Medical Attention):
Rheumatoid arthritis, an autoimmune disease, is characterized by the dysregulation of pro-inflammatory cytokines such as IL7, IL15, IL21, IL6, IFN-alpha, and IFN-beta. These cytokines signal through the Janus kinase (JAK) pathway, leading to tissue inflammation and joint damage by stimulating the recruitment and activation of immune cells.
Arthanib 5 mg, as a Partial and Reversible JAK Inhibitor:
Role of JAK-STAT Signaling Pathway:
Other Pathways and Efficacy:
In summary, Arthanib 5 mg's pharmacological action involves inhibiting the JAK-STAT signaling pathway, thereby reducing the inflammatory response associated with rheumatoid arthritis. The drug's partial and reversible JAK inhibition may also impact other pathways, enhancing its therapeutic effects.
Adult Dose for Rheumatoid Arthritis:
Dosage Adjustment for Hepatic Impairment:
Child Dose:
Dosage Adjustment for Renal Impairment:
Arthanib may be taken with or without food, but it is advised to take it at a fixed time each day. Swallow the tablet whole, without chewing or breaking.
Antibiotics:
Antifungals:
Immunosuppressive Medications:
Corticosteroids:
Before taking Arthanib 5mg Tablet, it is essential to inform your physician about any ongoing medications, as interactions can occur.
Hypersensitivity to the active substance or any of the excipients.
Pregnancy Category C. There are no adequate and well-controlled studies in pregnant women. Arthanib 5 mg should be used during pregnancy only if the potential benefit justifies the potential risk to the fetus.It is not known whether Arthanib 5 mg is excreted in human milk. Because many drugs are excreted in human milk and because of the potential for serious adverse reactions in nursing infants from Arthanib 5 mg, a decision should be made whether to discontinue nursing or to discontinue the drug, taking into account the importance of the drug for the mother
Store below 30°C. Protect from light & moisture. Keep all medicines out of the reach of children.
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