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Arthrofen Plus (75mg+20mg)/2ml Injection
The Arthrofen Plus (Diclofenac Sodium 75mg + Lidocaine 20mg)/2ml Injection is indicated for various therapeutic uses, including:
- Rheumatoid arthritis
- Osteoarthritis
- Lower back pain
- Ankylosing spondylitis
- Acute gout
- Acute trauma and fractures
- Control of pain and inflammation in orthopedic, dental, and other minor surgeries
- Juvenile chronic arthritis
- Postoperative pain
- The pain of renal colic
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✅ Description:
The Diclofenac Sodium and Lidocaine injection is used to relieve pain and inflammation in various conditions, including:
- Arthritic conditions such as rheumatoid arthritis, osteoarthritis, juvenile chronic arthritis, ankylosing spondylitis, and acute gout.
- Acute musculoskeletal disorders like peri arthritis (e.g., Frozen shoulder), tendinitis, tenosynovitis, and bursitis.
- Pain resulting from trauma such as fractures, low back pain, sprains, strains, and dislocations.
- Control of pain and inflammation in orthopedic, dental, and other minor surgeries, as well as postoperative pain and pain from renal colic.
The addition of Lidocaine in the injection serves as a local anesthetic, reducing the likelihood of pain at the injection site, especially after intramuscular administration. This combination provides relief from pain and inflammation while minimizing discomfort associated with the injection itself.
✔️ Overdose Effects:
Symptoms of acute NSAID overdoses include lethargy, drowsiness, nausea, vomiting, and epigastric pain, generally reversible with supportive care. Gastrointestinal bleeding, hypertension, acute renal failure, respiratory depression, and coma may occur but are rare. Anaphylactoid reactions have been reported with therapeutic NSAID ingestion and may occur after an overdose.
✔️ Dosage & Administration:
Each 2 ml ampoule contains Diclofenac Sodium 75 mg and Lidocaine Hydrochloride 20 mg.
- Adults: One ampoule once (or twice in severe cases) daily by intramuscular injection.
- Renal colic: One ampoule once daily intramuscularly, with a further ampoule administered after 30 minutes if necessary. The maximum daily dose of diclofenac is 150 mg, and for lidocaine, it is 200 mg.
- Children: In juvenile chronic arthritis, 1-3 mg of diclofenac/kg body weight daily in divided doses.
- Elderly patients: The lowest effective dosage recommended, adjusted for age and physical status.
✔️ Side Effects:
Side effects are usually mild and transient but may include gastrointestinal discomfort, nausea, diarrhea, bleeding, and injection site disorders. Rare instances of abscesses and local necrosis may occur. Lidocaine-related adverse effects are generally short-lived and may include CNS reactions like drowsiness, dizziness, and confusion.
✔️ Pregnancy & Lactation:
Use during pregnancy should be avoided unless compelling reasons exist. The lowest effective dosage should be used, especially in the last trimester. While small quantities of Diclofenac may be detected in breast milk, adverse effects on the infant are not expected.
✔️ Precautions & Warnings:
Close observation is recommended for patients with severe hepatic, cardiac, or renal insufficiency, or the elderly, as NSAIDs may worsen renal function. Monitor renal, hepatic function, and blood counts in long-term NSAID therapy. Discontinue Diclofenac if abnormal liver function tests persist or worsen.
✔️ Storage Conditions:
Store below 30°C in a dry place, protected from light.
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