Methotrexate hinders the growth of rapidly reproducing cells, notably cancer cells, bone marrow cells, and skin cells. It's employed to treat leukemia and specific cancers affecting the breast, skin, head, neck, lung, or uterus. Additionally, Methotrexate is used for severe psoriasis and rheumatoid arthritis in adults, as well as active polyarticular-course juvenile rheumatoid arthritis in children. It is often prescribed when other medications have proven ineffective.
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Methox 10mg Tablet is prescribed for various conditions. Primarily, it is used to treat severe psoriasis, rheumatoid arthritis that is not responsive to other treatments, and certain types of cancer such as breast cancer and leukemia. Methotrexate belongs to a class of medications called antimetabolites, which work by slowing the growth of cancer cells and skin cells.
In addition to its primary uses, Methotrexate is sometimes employed for conditions like Crohn's disease, multiple sclerosis, and other autoimmune diseases. Patients should be aware of potential risks associated with off-label use and consult their doctor accordingly.
Special precautions include informing the healthcare provider about allergies, current medications, and medical conditions. Methotrexate may require careful monitoring, especially in cases of surgery, and precautions against excessive sunlight exposure due to increased skin sensitivity. Vaccinations during treatment should be discussed with the doctor.
Patients are advised not to alter the dosage without consulting their doctor and to promptly report any side effects. Serious symptoms like blurred vision, seizures, or weakness require immediate medical attention.
Taking Methotrexate with alcohol increases the risk of liver damage.
Methox 10mg Tablet is highly unsafe to use during pregnancy.
Human and animal studies have shown significant adverse effects on the fetus. Please consult your doctor.
Methox 10mg Tablet is probably unsafe to use during breastfeeding. Please consult your doctor.
There is no interaction between driving and consuming this drug. So dose alteration is not needed.
Caution to be advised in patients with impaired renal function.
There is no data available. Please consult a doctor before consuming the drug.
It has an inhibiting effect on the enzyme tetrahydrofolate dehydrogenase which in turn prevents the synthesis of tetrahydrofolate, a compound necessary for the synthesis of thymidylate, an essential component of DNA.
Methox 10mg Tablet is used in the treatment of rheumatoid arthritis and psoriasis.
Methox 10mg Tablet inhibits the enzyme dihydrofolic acid reductase. This enzyme is essential for converting dihydrofolates into tetrahydrofolates, which are necessary as carriers of one-carbon groups in the synthesis of nucleotides and thymidylate. By interfering with this process, Methox 10mg Tablet disrupts DNA synthesis, repair, and cellular replication.
Tissues that actively proliferate, such as malignant cells, bone marrow, fetal cells, buccal and intestinal mucosa, and cells of the urinary bladder, are generally more sensitive to the effects of Methox 10mg Tablet. When cellular proliferation in malignant tissues surpasses that of most normal tissues, Methox 10mg Tablet may impede the growth of malignant cells without causing irreversible damage to normal tissues.
The administration of Methotrexate involves taking it orally as tablets. The dosage and schedule depend on the specific condition and individual response. For psoriasis and rheumatoid arthritis, it is often taken once a week. It is crucial to follow the prescribed schedule carefully, as incorrect daily intake can lead to severe side effects.
In case of a missed dose, patients should take it as soon as remembered, but a double dose should not be taken close to the next scheduled dose.
Drug-Drug Interactions: Methox 10mg Tablet may interact with:
Drug-Food Interactions: Avoid consuming alcohol while on treatment with Methox 10mg Tablet.
Drug-Disease Interactions: Inform your doctor if you have immunodeficiency conditions, bone marrow problems, low white blood cell count, low platelet count, serious anemia, liver problems due to alcohol abuse, or chronic liver disease.
Pregnancy category X. Studies in animals or human beings have demonstrated fetal abnormalities or there is evidence of fetal risk based on human experience or both, and the risk of the use of the drug in pregnant women outweighs any possible benefit. The drug is contraindicated in women who are or may become pregnant.
Talk to your doctor before taking Methox 10mg Tablet if you:
Storage should be in a tightly closed container at room temperature, away from children. Disposal should be done through medicine take-back programs to prevent accidental consumption.
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