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Brezofil Syrup (100ml)
Generics: Doxophylline 100/5mg/ml
Manufacturer: Incepta Pharmaceuticals Ltd.
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✅ Description:
Indications of Brezofil 100 ml
Doxophylline is utilized to treat asthma, COPD and bronchospasm.
Pharmaceutical Name of Brezofil 100 ml
Pharmacology
Doxophylline could be a novel bronchodilator. It structurally contrasts from Theophylline due to the nearness of a dioxolane bunch in position 7. Doxophylline specifically inhibits phosphodiesterase 4 subsequently unwinds bronchial smooth muscle. Be that as it may, in an unexpected way from Theophylline, Doxophylline shows up to have decreased affinities toward adenosine A1 and A2 receptors, which may account for the better safety profile of the sedate. Doxophylline is reported to restrain platelet actuating factor (PAF) and era of leukotriene generation.
Dosage & Administration
Elderly: 200 mg tablet two or three times daily.
Adults: 400 mg tablet two or three times daily or as endorsed by the physician.
Children:
▪ >12 a long time of age: 10 ml syrup or 200 mg tablet two or three times daily.
▪ 6-12 a long time of age: 6-9 mg/kg body weight two times day by day, i.e. on the off chance that body weight is 10 kg, 3 ml (60 mg) two times daily or as endorsed by the physician
On the off chance that required day by day measurements of Doxophylline is 400 mg then Doxophylline SR tablet to be taken once daily or as endorsed by the physician
Interaction of Brezofil 100 ml
Doxophylline ought to not be administered together with other xanthine subordinates. Toxic synergism with ephedrine has been documented for xanthines. Like other xanthines, concomitant treatment with troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol and anti-flu antibody may diminish the hepatic clearance of xanthines causing an increment in blood levels. No prove of a relationship between Doxophylline serum concentrations and poisonous occasions have been reported.
Contraindications
Doxophylline is contraindicated in acute myocardial localized necrosis. It is additionally contraindicated in patients with hypotension, in lactating women & patients who have shown hypersensitivity to its components
Side Effects of Brezofil 100 ml
Doxophylline seldom causes genuine side effects, be that as it may conceivable side impacts are similar for taking abundance sum of caffeine. These incorporate: queasiness, spewing, headache, upset stomach and acid reflux.
Pregnancy & Lactation
Creature propagation considers show that, Doxophylline does not cause fetal hurt when administered to pregnant creatures or can not affect generation capacity. Be that as it may, since there is constrained involvement in human during pregnancy, xanthines ought to be given to pregnant ladies as it were on the off chance that clearly needed. Doxophylline is contraindicated in nursing mothers.
Precautions & Warnings
The half-life of xanthine subsidiaries is influenced by a number of known factors. It may be drawn out in patients with liver disease, in patients with congestive heart disappointment and in those patients taking certain other drugs like erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propanolol and anti-flu vaccine. In these cases, a lower dosage of Doxophylline may be required. Phenytoin, other anticonvulsants and smoking may cause an increase in clearance with a shorter mean half-life. In these cases higher measurements of Doxophylline may be needed.
Therapeutic Class
Bronchodilator, Methyl xanthine subsidiaries
Storage Conditions
Keep in a dry put absent from light and heat. Keep out of the reach of children. Doxophylline should be utilized as it were on medicine of specialist doctor.
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