Contine 400 mg 10 Pcs - ePharma
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Home Medicines Asthma Contine 400mg 10Pcs
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Contine 400mg 10Pcs

Generic: Theophylline anhydrous

Type: Tablet

Pack Size: 10 Pcs

Tablet Manufacturer/Distributor: Aristopharma Limited Generic Name: Theophylline anhydrous 400mgl tablet (sustained release)


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Discount Price: ৳ 27.8
MRP: ৳ 29.89 7% Off

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✅ Description:

Indications

Theophylline is used to treat acute asthma attacks.

Chronic asthma management (For both Symptomatic and prophylactic treatment).

For nighttime asthma and early morning wheeze management.

Acute exacerbation of chronic obstructive pulmonary disease (Chronic bronchitis and emphysema) and management of chronic obstructive pulmonary disease (Chronic bronchitis and emphysema).

Control of prematurity apnea.

 

Pharmacology

Theophylline is a bronchodilator categorized as a Methylxanthine structurally. Smooth muscle relaxation and inhibition of the airways' responsiveness to stimuli are two different effects of theophylline in the airways of individuals with reversible blockage. Theophylline also enhances the power of diaphragmatic muscle contraction. A number of known factors impact the half-life of theophylline. The half-life of adult nonsmokers with uncomplicated asthma ranges from 3 to 9 hours.

 

Dosage & Administration

The dose of theophylline must be individualized on the basis of peak serum theophylline concentration measurements in order to achieve a dose that will provide maximum potential benefit with minimal risk of adverse effects. Most of the sustained release preparations may be administered every 12 hours in adults while administration every 8 hours may be necessary in some children with markedly rapid hepatic
metabolism of theophylline. The recommended maintenance dose within accepted therapeutic range is as follows :

 

16 years or older: 10 mg/Kg/day (Do not exceed 900 mg/day)

12 years-15 years: 13 mg/Kg/day

9-11 years: 16 mg/Kg/day

1 year-8 years: 24-24 mg/Kg/day

6 months-1 year: 12-18 mg/Kg/day

1-6 months: 10 mg/Kg/day.

 

Interaction

Theophylline should not be used simultaneously with other preparations containing xanthine derivatives. Barbiturates, carbamazepine, lithium, phenytoin, rifampicin, and sulfopridone can increase theophylline clearance, so an increased dose may be required. On the other hand, allopurinol, cimetidine, ciprofloxacin, corticosteroids, erythromycin, furosemide, isoproterenol, oral contraceptives, and thiabendazole reduce the drug clearance rate, so it may The dose needs to be reduced to avoid side effects. Theophylline can aggravate hypokalemia caused by β2 receptor agonist therapy, steroids, diuretics, and hypoxia, so serum potassium levels should be controlled in this case.

 

Contraindications

Patients who are hypersensitive to theophylline or any other component of the product should avoid using it.

 

Side Effects

At regular dosages, adverse effects are uncommon. GI pain, headaches, nausea, sleeplessness, and hypotension are all possible symptoms. Diuresis and CNS stimulation are also possible, especially in youngsters.

 

Pregnancy & Lactation

It is unknown if theophylline can damage a developing fetus when given to a pregnant woman. Only if obviously needed should xanthines be administered to a pregnant lady. In nursing human babies, theophylline is secreted in breast milk and may induce agitation or other indications of moderate poisoning. Unless the mother has hazardous serum Theophylline concentrations, serious adverse consequences in the child are unlikely.

Precautions & Warnings

Various interacting medications and physiologic circumstances that might affect Theophylline clearance must be carefully considered. Before to starting Theophylline therapy, prior to increasing the Theophylline dose, and throughout follow-up, dosage adjustments are necessary. The dose of Theophylline used for beginning of therapy should be modest and gradually raised over time if tolerated.

Storage Conditions

Keep all medicines out of reach of children. Store in a cool and dry place, protected from light.

 

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