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Doxiflo is indicated for the treatment and management of:
- Bronchial Asthma
- Bronchospasm
- Chronic Obstructive Pulmonary Disease (COPD)
- Pulmonary disorders with spastic bronchial components
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Price: ৳ 59
MRP:
৳
60
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Cash on Delivery - All over Bangladesh
Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
- Cash on Delivery - All over Bangladesh
- Regular Delivery - 12-24 Hours, Dhaka City* Charge Tk.39-59
- Regular Delivery - 24-48 Hours, Other Cities* Charge Tk.99-110
- ফ্রি ডেলিভারিঃ - ৯৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে
- ফ্রি ডেলিভারিঃ - ২৯৯৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Doxophylline is a novel bronchodilator structurally related to theophylline but distinguished by the presence of a dioxolane group at position 7.
It acts by selectively inhibiting phosphodiesterase-4 (PDE-4), resulting in bronchial smooth muscle relaxation and improved airflow.
Unlike theophylline, Doxophylline has a lower affinity for adenosine A1 and A2 receptors, which contributes to its better safety and tolerability.
Additionally, it inhibits platelet-activating factor (PAF) and leukotriene synthesis, offering anti-inflammatory benefits.
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✔️ Dosage & Administration
Adults:
400 mg tablet two or three times daily, or as prescribed by the physician.
Elderly:
200 mg tablet two or three times daily.
Children:
>12 years: 200 mg tablet or 10 ml syrup two or three times daily.
6–12 years: 6–9 mg/kg body weight twice daily (e.g., 3 ml syrup or 60 mg twice daily for a 10 kg child).
For a daily requirement of 400 mg, the Doxophylline SR tablet may be taken once daily.
✔️ Common adverse reactions include:
Nausea, vomiting, epigastric pain
Headache, insomnia, irritability, dizziness
Tachycardia, palpitations, tachypnea
Rarely, hyperglycemia or albuminuria
✔️ Interaction
- Avoid co-administration with other xanthine derivatives or caffeine-containing foods/beverages.
- Use cautiously with ephedrine or sympathomimetic agents.
- Drugs such as erythromycin, cimetidine, clindamycin, allopurinol, propranolol, and influenza vaccine may reduce hepatic clearance of Doxophylline, leading to increased plasma levels.
- Phenytoin, anticonvulsants, and cigarette smoking may increase clearance, reducing its effect — dose adjustment may be needed.
✔️ Contraindications:
Known hypersensitivity to Doxophylline or other xanthine derivatives
- Acute myocardial infarction
- Hypotension
- During lactation
✔️ Pregnancy & Lactation
- Animal studies show no adverse effects on prenatal or postnatal growth, but human data are limited.
- Use during pregnancy only if benefits outweigh potential risks.
- Contraindicated during lactation, as safety in breastfeeding is not established.
✔️ Precautions & Warnings
Reduced hepatic clearance may occur in elderly patients and those with heart failure, COPD, liver disease, or infections — dose adjustment and drug level monitoring are recommended.
- Use cautiously in hypertension, peptic ulcer, renal impairment, hyperthyroidism, and hypoxemia.
- Clearance is slower in congestive heart failure, potentially causing prolonged elevated levels.
- No risk of addiction or dependency.
✔️ Storage Condition
Store in a cool, dry place below 30°C, away from light and moisture.
Keep out of the reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
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