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Indications
Montelukast Sodium is indicated for:
Pharmacology
Montelukast may be a particular and orally dynamic leukotriene receptor opponent that represses the cysteinyl leukotriene receptor (CysLT1). The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are items of arachidonic corrosive digestion system and are discharged from different cells, counting pole cells and eosinophils. Cysteinyl leukotrienes and leukotriene receptor occupation have been connected with the pathophysiology of asthma & unfavorably susceptible rhinitis, counting aviation route edema, smooth muscle compression, and modified cellular action related with the fiery prepare, which contribute to the signs and indications of asthma.
Dosage & Administration
Adults & adolescents (15 years & older)-
Asthma & Allergic Rhinitis: 10 mg/day
Exercise-Induced Bronchoconstriction: 10 mg/day
Pediatric patients (6 to 14 years)-
Asthma & Allergic Rhinitis: 5 mg/day
Exercise-Induced Bronchoconstriction: 5 mg/day
Pediatric patients (6 months to 5 years)-
Asthma & Allergic Rhinitis: 4 mg/day
Exercise-Induced Bronchoconstriction: Not recommended
Patients with both asthma and allergic rhinitis should take only one dose daily in the evening. For prevention of Acute prevention of Exercise-Induced Bronchoconstriction, a single dose should be taken at least 2 hours before exercise.
Interaction
With medication: No dosage alteration is required when montelukast is co-administered with theophylline, prednisone, prednisolone, terfenadine, digoxin, warfarin, gemfibrozil, itraconazole, thyroid hormones, sedative-hypnotics, non-steroidal anti-inflammatory specialists, benzodiazepines, decongestants, verbal contraceptives, and Cytochrome P450 (CYP) protein inducers. With nourishment and others: Bioavailability and other conditions were not altogether watched with nourishment & other conditions.
Contraindications
Montelukast is contraindicated in patients who are hypersensitive to any component of this product.
Side Effect
Common: Loose bowels, fever, gastrointestinal inconvenience, migraine, queasiness, heaving, skin responses, upper respiratory tract infection. Uncommon: Akathisia, uneasiness, arthralgia, asthenia, unusual behavior, sadness, discombobulation, laziness, dry mouth, discharge, fractiousness, disquietude, muscle complaints, oedema, seizure, irregular sensation, rest disorders. Rare: Angioedema, concentration impeded, confusion, eosinophilic granulomatosis with polyangiitis, erythema nodosum, visualization, hepatic clutters, memory misfortune, palpitations, pneumonic eosinophilia, self-destructive inclinations, tremor.
Pregnancy & Lactation
There are no adequate and well-controlled studies in pregnant women. Montelukast should be used during pregnancy only if clearly needed. Montelukast is excreted in breast milk. So caution should be exercised when Montelukast is given to a nursing mother.
Precautions & Warnings
Montelukast is not indicated for use in the reversal of bronchospasm in acute asthma attacks, including status asthmatic. Neuropsychiatric events including agitation, hostility, anxiousness, depression, disorientation, disturbance in attention, dream abnormalities, hallucinations, insomnia, irritability, memory impairment, restlessness, somnambulism, suicidal thinking and behavior (including suicide) and tremor.
Storage Conditions
Store in cool & dry place below 30°C, protect from light & moisture. Keep out of reach of children.
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