Xofyl 400, 1 Strip

✔️ Xofyl 400 mg is indicated for the management of respiratory conditions associated with bronchial smooth muscle spasm, including:

• Bronchial asthma
• Bronchospasm
• Chronic obstructive pulmonary disease (COPD)
• Pulmonary disorders with a spastic bronchial component

✔️ Dosage & Administration

Adults:

400 mg tablet two to three times daily, or as directed by the physician

Elderly:

200 mg tablet two to three times daily

Children:

Above 12 years: 10 ml syrup or 200 mg tablet two to three times daily

6–12 years: 6–9 mg/kg body weight twice daily

Example: For a child weighing 10 kg, 3 ml (60 mg) twice daily

Dosage should be individualized based on patient response and clinical condition.

✔️ Xofyl 400 mg is generally well tolerated. When side effects occur, they are usually mild and resemble those associated with excessive caffeine intake, including:

• Nausea and vomiting
• Headache
• Gastrointestinal discomfort
• Heartburn

✔️ Drug Interaction

Xofyl 400 mg should not be used concurrently with other xanthine derivatives. Concomitant use with ephedrine may result in toxic synergistic effects.

As with other xanthines, drugs such as troleandomycin, lincomycin, clindamycin, allopurinol, cimetidine, ranitidine, propranolol, and influenza vaccines may reduce hepatic clearance, leading to increased plasma concentrations.

No clear correlation has been established between serum levels of Xofyl® and the occurrence of toxic effects.

✔️ Xofyl 400 mg is contraindicated in:

Acute myocardial infarction

Patients with hypotension

Lactating women

Individuals with known hypersensitivity to any component of the formulation

✔️ Pregnancy & Lactation

Animal studies have shown no evidence of fetal harm or impaired reproductive capacity. However, due to limited data in humans, Xofyl 400 mg should be used during pregnancy only if clearly necessary.

Xofyl 400 mg is contraindicated during breastfeeding.

✔️ Precautions & Warnings

The elimination half-life of xanthine derivatives may be prolonged in patients with:

• Hepatic impairment
• Congestive heart failure

Concomitant use of drugs such as erythromycin, troleandomycin, lincomycin, allopurinol, cimetidine, propranolol, or influenza vaccines

Dose reduction may be required in these situations. Conversely, smoking and anticonvulsants (e.g., phenytoin) may increase drug clearance, necessitating higher doses.

Careful clinical monitoring is recommended during therapy.

✔️ Storage:

Store in a cool, dry place away from light and heat. Keep out of reach of children.
Xofyl 400 mg should be used only on the prescription of a specialist physician.