K-One MM Injection

✔️ Uses of K-One MM Injection

• Vitamin K Deficiency
• Abnormal Heavy Bleeding

✔️ Side Effects of K-One MM Injection

• Dizziness
• Flushing
• Changes in taste
• Sweating

✔️ How does K-One MM Injection work?

K-One MM is a synthetic form of vitamin K. It restores the activity of vitamin K and speeds up the normal blood clotting process to prevent or treat bleeding caused due to too high dose of warfarin.

✔️ Quick Suggestions:

• Do not take phytomenadione tablets if you are allergic (hypersensitive) to phytomenadione or any of the other ingredients of phytomenadione formulation.
• Do not use phytomenadione if you have glucose-6-phosphate dehydrogenase (G6PD) deficiency (a disorder in which the red blood cells are destroyed faster leading to anemia).
• Do not use it as an antidote for heparin.

✔️ Indication

K-One MM is a medication utilized to address vitamin K deficiency within the body. It effectively helps to alleviate conditions that arise due to insufficient levels of vitamin K. Vitamin K plays a crucial role in blood clotting and bone metabolism, making it an essential nutrient. This medication is administered under the careful supervision of a healthcare professional and should not be self-administered. Consistent adherence to the prescribed regimen is essential for maximizing its benefits.

K-One MM should be viewed as a component of a comprehensive treatment plan, which may also encompass dietary adjustments and vitamin supplementation. Generally, K-One MM is considered safe and is associated with minimal or no side effects. However, some individuals may experience discomfort such as pain, redness, or swelling at the injection site. It's recommended to inform your doctor about all other medications you are taking to ensure safety and avoid potential interactions. Consulting a healthcare provider before introducing any additional vitamin supplements is important.

In summary, K-One MM serves to address vitamin K deficiency, promoting improved health outcomes related to this deficiency. As with any medication, it's advisable to follow medical guidance and recommendations closely to achieve the desired therapeutic effects and minimize risks.

✔️ Pharmacology

Phytomenadione acts as a procoagulant factor. It plays a critical role in the hepatic carboxylase system, participating in the process of post-translational carboxylation of various clotting factors including II (prothrombin), VII, IX, and X, as well as the anticoagulant proteins protein C and protein S. However, it's important to note that Phytomenadione is not effective in cases of genetic hypoprothrombinemia or hypoprothrombinemia triggered by severe liver failure.

When Phytomenadione is deficient, there is an increased susceptibility to hemorrhagic disorders in infants. The administration of Phytomenadione helps promote the synthesis of the aforementioned coagulation components within the liver. This can reverse abnormal coagulation conditions and prevent fatal outcomes associated with Phytomenadione deficiency.

✔️ Dosage & Administration of K-One MM Injection

Here are the dosage recommendations for different scenarios and age groups involving vitamin K supplementation:

Adult Dose:

Oral Vitamin K Deficiency due to Drugs or Malabsorption:

• Adult: 10-40 mg daily.

Over-Anticoagulation:

• Adult: Up to 5 mg may be used. The specific dose depends on the International Normalized Ratio (INR) and the severity of the hemorrhage.

Intravenous Over-Anticoagulation:

• Adult: Administer 0.5-5 mg via slow intravenous injection. The dose is determined by the INR and the extent of the bleeding.

Child Dose:

Intramuscular Prophylaxis of Vitamin K Deficiency Bleeding in Neonates:

• Child (Neonate): Administer 0.5-1 mg as a single dose through intramuscular injection. Alternatively, an oral dosage of 2 mg can be given initially, followed by a second oral dose of 2 mg after 4-7 days.

Parenteral Vitamin K Deficiency Bleeding in Neonates:

• Child (Infant): Administer 1 mg via intravenous, intramuscular, or subcutaneous injection. Further doses may be administered if deemed necessary.

✔️ Interaction

Drug-Drug Interactions: Phytomenadione can potentially interact with various medications. These interactions may include:

• Anticoagulants: Such as warfarin, dicumarol, and anisindione.
• Bile Acid Sequestrants: Like cholestyramine, colesevelam, and colestipol.
• Lipase Inhibitor: Such as orlistat.
• Phosphate Binder: Like sevelamer.
• Pain Relievers: Including aspirin.
• Antibiotics: Such as cefaclor, cefuroxime, cefadroxil, and ceftriaxone.

Drug-Food Interactions: No interactions between Phytomenadione and food have been identified.

Drug-Disease Interactions: It's crucial to inform your doctor if you have a history of specific medical conditions before using Phytomenadione. These conditions include:

• Liver Disease
• Cholestatic Disease (disruption in bile flow in the body)
• Kidney Diseases
• Heart Diseases
• Blood Disorders

✔️ Contraindications

It is contraindicated in patients with known touchiness to any of its constituents.

✔️ Pregnancy & Lactation

Cautious observing of the coagulation parameters is essential for patients with seriously impeded liver work after the organization of Phytomenadione.

✔️ Precautions & Warnings

If you have a known allergy to Phytomenadione or any other medications, it's crucial to inform your doctor. For individuals who are pregnant or breastfeeding, it's recommended to consult a doctor before using Phytomenadione. It's important to communicate any prescription and non-prescription medications, including vitamin supplements, that you are taking with your doctor prior to starting Phytomenadione.

Additionally, if you have a history of liver disease, cholestatic disease (a condition affecting bile flow), kidney disease, or heart disease, it's essential to inform your doctor before taking Phytomenadione. This information is vital for ensuring your safety and well-being when using this medication. Always consult a healthcare professional before starting any new medication, especially if you have pre-existing medical conditions or are taking other medications.

✔️ Storage Conditions

Keep below 30°C temperature, absent from light & dampness. Keep out of the reach of children.