Xamic 500mg Capsule 10pcs

Uses of Xamic 500

• Bleeding

How does Xamic 500 work?

It works by preventing the breakdown of blood clots to control excessive bleeding during periods, or after surgery.

Side Effects of Xamic 500

• Generally well tolerated.
• Possible side effects: Fatigue, conjunctival irritation, nasal blockage, itching, skin redness, exanthems, nausea, diarrhea, gastric pyrosis, and rare cases of postural hypotension.
• Discontinue use if hypersensitivity occurs.

Quick Suggestions:

• Tranexamic Acid helps prevent or reduce heavy bleeding post-surgery and in conditions such as heavy periods, dysfunctional uterine bleeding, and nosebleeds.
• Your doctor will prescribe the lowest effective dose for the shortest possible time necessary to relieve your symptoms.
• If taking it for heavy periods, take it on the first day as taking it before or after will not have any benefit.
• Your doctor may monitor your vision regularly while you are taking this medicine.
• Inform your doctor if you have a history of kidney or liver disease.
• Inform your doctor if there is no improvement in your bleeding after using this medicine for three consecutive periods.

Indications:

Xamic 500 is indicated for the management of bleeding in various conditions, including:

• Heavy menstrual bleeding in women
• Bleeding inside the digestive system (e.g., inflammatory bowel disease)
• Nosebleeds (epistaxis)
• Hematuria (blood in urine) not caused by kidney parenchyma
• Bleeding control after dental extractions in patients with coagulopathies
• Bleeding after cervix surgery

Pharmacology

Tranexamic acid (trans-4 aminomethyl-cyclohexanecarboxylic acid) is a strong antifibrinolytic agent, effective in inhibiting the activation of plasminogen to plasmin, which is essential for clot breakdown. It acts by preventing the binding of plasminogen to fibrin, thereby inhibiting fibrinolysis. Tranexamic acid is more effective and long-lasting than conventional hemostatic agents due to its slower excretion via the renal route and higher potency. It does not interfere with normal clotting processes and has low acute and chronic toxicity.

Dosage & Administration of Xamic 500

Adults:

• Usual dose: 500-1000 mg three times daily.
• Prophylaxis: 0.5-1 g daily orally, or 500 mg intravenously or intramuscularly.
• Therapy for hemorrhagic manifestations: 1-3 g daily in divided doses. In severe cases, start with 500 mg intravenously, followed by oral doses as required.

Children:

• Prophylaxis: 5-10 mg/kg daily in divided doses.
• Therapeutic: 10-20 mg/kg daily orally, or 10 mg/kg intravenously or intramuscularly. Oral administration of diluted ampoules is an option for small children.

Elderly:

• No dosage reduction is necessary unless there is renal impairment.

Interaction

• Incompatible with: Solutions containing penicillins.
• Antagonistic drugs: Thrombolytics like streptokinase and urokinase.
• Potential thrombus formation is increased by: Estrogen-containing drugs like oral contraceptives.
• Avoid direct admixture with whole blood during transfusion.

Contraindications

• Hypersensitivity to tranexamic acid or any components of the formulation.
• Thromboembolic disease, arterial and venous thrombosis.
• Endocavitary hemorrhages.
• Severe renal failure.

Pregnancy & Lactation

• Avoid during pregnancy due to unknown transplacental effects.
• Tranexamic acid passes into breast milk in low concentrations, making antifibrinolytic effects in infants unlikely.

Precautions & Warnings

• Use with caution in patients with hyperfibrinolysis.
• Prophylactic treatment should start 24 hours before surgery and continue for 3-4 days post-operation.
• For hemorrhages, continue therapy for at least 24 hours after symptoms subside.
• Reduce doses in hematuria to prevent urinary tract clots.
• Avoid use in severe renal dysfunction; use cautiously in mild to moderate renal impairment.
• Requires careful administration in patients with heart or liver conditions.

Storage Conditions:

Store in a dry place at 15-30°C, protected from light. Keep out of reach of children.