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Calciferol 200000IU Injection
Cholecalciferol (Vit. D3) 5 mg/ml Injection is used for
- Vitamin D3 Deficiency: Common in individuals with limited sunlight exposure or poor dietary intake of Vitamin D3. It is essential for calcium and phosphate absorption, necessary for healthy bones and teeth, and helps prevent conditions like rickets, osteomalacia, and osteoporosis.
- Pregnancy and Breastfeeding: Vitamin D3 prevents pre-eclampsia and is crucial for the developing infant. It also plays a significant role in boosting immunity.
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✅ Description:
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✔️ Pharmacology
- The active form of Vitamin D3 is Calcitriol, which binds to Vitamin D receptors (VDRs) in various tissues.
- Absorbed in the small intestine, Vitamin D3 is bound to specific a-globulins and transported to the liver where it is converted to 25-hydroxy Vitamin D3 (Calcidiol). Further hydroxylation occurs in the kidney to form 1,25-dihydroxy Vitamin D3 (Calcitriol), which is responsible for increasing calcium absorption.
- Elimination: Excreted via feces and urine, with non-metabolized Vitamin D3 stored in tissues like fat and muscle.
- Half-Life: Approximately 50 days, being fat-soluble.
✔️ Dosage of Calciferol IM Injection
- Prevention:
- Infants with Vitamin D Enriched Milk: ½ ampoule (0.5 ml, 100,000 IU) every 6 months.
- Other Infants & Young Children: 1 ampoule (1 ml, 200,000 IU) every 6 months.
- Adolescents: 1 ampoule (1 ml, 200,000 IU) every 6 months during winter.
- Pregnancy: ½ ampoule (0.5 ml, 100,000 IU) from the 6th or 7th month of pregnancy.
- Elderly: ½ ampoule (0.5 ml, 100,000 IU) every 3 months.
- Special Conditions: ½ or 1 ampoule (100,000-200,000 IU) every 3-6 months.
- Deficiency: 1 ampoule (1 ml, 200,000 IU) can be repeated after 1-6 months.
✔️ Before taking Calciferol IM Injection, inform your doctor, if you are taking any of the following medicines:
- Medicines used to manage epilepsy (Ex. carbamazepine, phenobarbital, phenytoin, primidone)
- Other vitamin D-containing medicines including multi-vitamins
- Medicines to control the rate of your heartbeat (Ex. digoxin, digitoxin)
- Diuretics (water tablets) (Ex. Bendroflumethiazide)
- Calcium supplements
- Medicines used to manage tuberculosis (Ex. rifampicin, isoniazid)
- Medicines leading to fat malabsorption (Ex. orlistat, cholestyramine, liquid paraffin)
- Medicines used to manage fungal infections (Ex. ketoconazole, itraconazole)
- Actinomycin (medicine used to manage some forms of cancer)
- Glucocorticosteroids Ex. hydrocortisone or prednisolone (used to manage inflammatory conditions)
✔️ Contraindications
- Hypercalcemia: Contraindicated in all conditions with high calcium levels.
- Hypersensitivity: Avoid in patients with known hypersensitivity to Vitamin D3 or its components.
- Vitamin D3 Toxicity: Should not be used if there is evidence of toxicity.
✔️ Side Effects
- Rare symptoms may include anorexia, lassitude, nausea, vomiting, diarrhea, constipation, weight loss, polyuria, sweating, headache, thirst, vertigo, and increased calcium and phosphate levels in plasma and urine.
✔️ Pregnancy & Lactation
- Pregnancy: Doses up to 4,000 IU are safe. The daily intake recommendation is 400 IU, but higher doses may be needed for deficiency. Follow medical advice based on individual needs.
- Lactation: Vitamin D3 and its metabolites are excreted in breast milk. Overdose in infants via breastfeeding has not been observed, but caution is advised when supplementing both mother and child.
✔️ Precautions & Warnings
- Regular plasma-calcium concentration monitoring is required in high doses, renal impairment, and during pregnancy & lactation.
- Consult a healthcare provider if using Digoxin, Thiazide Diuretics, or in cases of liver or kidney disease, hyperthyroidism, lymphoma, tuberculosis, and granulomatous disease.
✔️ Storage:
Store in a cool and dry place away from sunlight
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