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D-Rise 200000IU/ml Injection
Cholecalciferol [Vitamin D3] 200000IU/ml Injection
Prevention:
- Infants (on fortified milk): 100,000 IU every 6 months.
- Nursed infants & children <5 yrs: 200,000 IU every 6 months.
- Adolescents: 200,000 IU every 6 months (especially in winter).
- Pregnancy: 100,000 IU in the 6th–7th month.
- Elderly: 100,000 IU every 3 months.
Treatment: 200,000 IU; repeat every 1–6 months as needed.
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✅ Description:
D-Rise (Cholecalciferol) helps prevent and treat Vitamin D3 deficiency, especially in individuals with limited sunlight exposure or insufficient dietary intake. It promotes optimal absorption of calcium and phosphate, which is crucial for healthy bones, teeth, and immune function. Additionally, it plays a key role in preventing rickets, osteomalacia, osteoporosis, and pre-eclampsia during pregnancy.
Vitamin D3 (Cholecalciferol) is absorbed in the small intestine, binds to α-globulins, and is transported to the liver, where it's converted to Calcidiol (25-hydroxyvitamin D3). A second conversion occurs in the kidney to form the active hormone Calcitriol (1,25-dihydroxyvitamin D3). This active form binds to Vitamin D receptors (VDRs) in various tissues, enhancing calcium absorption and supporting bone mineralization. Vitamin D3 is fat-soluble, with a half-life of ~50 days, and is excreted via feces and urine.
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✔️ Side Effects
- Anorexia, nausea, vomiting
- Diarrhea or constipation
- Polyuria, weight loss, headache
- Increased calcium/phosphate levels in blood/urine
✔️ Interactions
Vitamin D3 absorption or metabolism may be reduced by:
- Antiepileptics (phenytoin, phenobarbital)
- Cholestyramine, colestipol, mineral oil, orlistat
- Corticosteroids (e.g., prednisolone)
- Magnesium-containing antacids
- Digoxin, thiazide diuretics
✔️ Contraindications
Hypercalcemia-related conditions
Known hypersensitivity to vitamin D3 or formulation excipients
Signs of vitamin D toxicity
✔️ Pregnancy & Lactation
Safe up to 4,000 IU/day in pregnancy.
Recommended intake: 400 IU/day (may be adjusted by physician based on need).
No evidence of overdose effects in infants via breastfeeding.
✔️ Precautions & Warnings
Monitor serum calcium in high-dose users, renal impairment, pregnancy, or lactation.
Use cautiously in:
- Patients on digoxin or thiazide diuretics
- Those with liver/kidney disease, lymphoma, TB, or granulomatous disorders
- In breastfeeding mothers, vitamin D3 is excreted in milk. Consider total infant exposure when supplementing both mother and child.
✔️ Storage
Store below 30°C, protected from light and moisture.
Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
