Cyclophosphamide, the active ingredient in Cyphos, is primarily metabolized in the liver into active alkylating agents. These metabolites inhibit the growth of rapidly dividing malignant cells by cross-linking DNA, interfering with cellular replication.
Key pharmacological properties:
In patients with kidney impairment, metabolites may accumulate, though no consistent evidence suggests a need for dose adjustment.
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Cyphos, while effective as a standalone treatment for certain malignancies, is often used in combination or sequentially with other antineoplastic medications. The following conditions are commonly responsive to Cyphos therapy:
Nonmalignant Indication:
Digestive System:
Skin:
Hematopoietic System:
Urinary System:
Respiratory System:
Other:
Oral:
Intravenous (IV) Preparation:
Bladder Toxicity Precaution:
Malignant Diseases:
Nephrotic Syndrome:
Non-Hodgkin’s Lymphoma:
Breast Cancer:
Malignant Diseases:
Juvenile Idiopathic Arthritis/Vasculitis:
Nephrotic Syndrome:
Systemic Lupus Erythematosus:
These dosage and administration guidelines should be followed under the close supervision of a healthcare provider to ensure safety and efficacy.
There is no specific antidote for Cyphos overdose. Supportive care should include treatment for infections, myelosuppression, or cardiac toxicity, as needed.
Store at temperatures below 25°C in a dry place, protected from light and moisture. Do not freeze.
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