✔ 100% Authentic Product
👁️ Currently Viewing 474
Eloxatin 50mg Infusion 10ml
Oxaliplatin undergoes nonenzymatic conversion in physiologic solutions, forming active derivatives that bind to DNA, leading to cross-linking. These crosslinks, between guanine bases and other nucleotides, prevent DNA replication and transcription, causing cytotoxic effects that are not dependent on the cell cycle. Oxaliplatin has shown antitumor activity in colon carcinoma and, in combination with 5-fluorouracil, has enhanced antiproliferative effects compared to either compound alone in various tumor models (colon, mammary, leukemia).
100% Genuine Products, Guaranteed
Safe & Secure Payments, Always
Fast, Secure & Efficient Delivery
Proper Packaging
Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Eloxatin, used in combination with infusional 5-fluorouracil/folinic acid, is indicated for:
- Adjuvant treatment of stage III colon cancer in patients who have undergone complete resection of the primary tumor.
- Treatment of advanced colorectal cancer.
Follow your registered healthcare provider’s advice regarding dosage and administration.
✔️ Dosage & Administration of
Administer oxaliplatin with 5-fluorouracil/folinic acid every 2 weeks. For advanced disease, continue treatment until disease progression or unacceptable toxicity. For adjuvant use, the treatment duration should be 6 months (12 cycles).
Day 1:
- Oxaliplatin 85 mg/m² IV infusion in 250-500 mL 5% Dextrose, followed by folinic acid 200 mg/m² IV infusion over 120 minutes.
- Then, administer 5-fluorouracil 400 mg/m² IV bolus (2-4 minutes), followed by 5-fluorouracil 600 mg/m² IV infusion in 500 mL 5% Dextrose for 22 hours.
Day 2:
- Folinic acid 200 mg/m² IV infusion over 120 minutes, followed by 5-fluorouracil 400 mg/m² IV bolus and 600 mg/m² IV infusion in 500 mL 5% Dextrose for 22 hours.
Follow your registered healthcare provider’s advice regarding dosage and administration.
✔️ Uses of Eloxatin
- Treatment of Colon and rectal cancer
✔️ Common side effects (incidence 40%) include:
- Peripheral sensory neuropathy, neutropenia, thrombocytopenia, anemia, nausea
- Increased liver enzymes (transaminases, alkaline phosphatase), diarrhea, vomiting, fatigue, stomatitis.
Other serious side effects may also occur.
✔️ Interactions
There are no specific cytochrome P-450 interaction studies. No pharmacokinetic interaction was observed between 85 mg/m² Eloxatin and 5-fluorouracil/folinic acid when dosed every 2 weeks. Higher doses (130 mg/m² every 3 weeks) may increase 5-fluorouracil plasma concentrations by about 20%. The clearance of platinum-containing compounds may be affected by nephrotoxic drugs.
✔️ Contraindications
Eloxatin is contraindicated in patients with a known allergy to oxaliplatin or other platinum-based compounds.
✔️ Overdose Effects
There is no known antidote for overdose. Overdose symptoms may include thrombocytopenia, hypersensitivity reactions, myelosuppression, nausea, vomiting, diarrhea, neurotoxicity, and severe respiratory or cardiac symptoms. Supportive treatment should be administered if an overdose occurs. The maximum single infusion dose recorded is 825 mg.
✔️ Pregnancy & Lactation
Pregnancy Category D. Eloxatin may cause fetal harm and should be avoided during pregnancy. Women of childbearing potential should avoid pregnancy during treatment. It is unknown if oxaliplatin is excreted in breast milk; consider discontinuing breastfeeding or the drug based on its importance to the mother.
✔️ Precautions & Warnings
- Allergic Reactions: Severe allergic reactions, including anaphylaxis, can occur and require discontinuation of therapy.
- Neurological Toxicity: Monitor for neurological effects, particularly if combined with other neurotoxic drugs.
- Pulmonary Toxicity: Eloxatin may cause pulmonary fibrosis, which can be fatal. Discontinue if respiratory issues arise.
- Hepatotoxicity: Liver function should be monitored for signs of liver sinusoidal obstruction syndrome.
- Cardiovascular Toxicity: Monitor for QT prolongation and arrhythmias, especially in patients with heart issues or electrolyte abnormalities.
✔️ Storage Conditions
Store in a cool, dry place, protected from light and moisture. Keep out of reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
Pricing Information, Availability:
ePharma reserves the right to make adjustments to pricing,
Products and Service offerings for reasons including, but not limited
to,
changing market conditions, Product discontinuation, Product
unavailability,
manufacturer price changes, supplier price changes and errors in
advertisements.
All orders are subject to Product availability and the availability of
Personnel to perform the Services.
Therefore, Seller cannot guarantee that it will be able to fulfill
Customer’s orders.
If Services are being performed on a time and materials basis, any
estimates provided
by Seller are for planning purposes only.
Reliable
All products displayed on ePharma are procured from govt. approved pharmaceuticals and verified licensed pharmacies from 2016.
Secure
ePharma uses Secure Sockets Layer (SSL) 128-bit 🔒 encryption and is Payment Card Industry DataSecurity Standard (PCI DSS) compliant.
Affordable
Find affordable medicine substitutes, save up to 50% on health products, up to 30% off on doctor consultations.
Social
Providing health care services under the health and beauty category with more than 170K Facebook audience and 10M+ reach.
Get more features!
Download the app now
🇬✓ Doctor consultation ✓ 24/7 helpline
