Folinex 15mg Tablet | Folinic Acid | Beacon Pharmaceuticals
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Folinex 15mg Tablet

Generic: Folinic Acid

Type: Tablet

Pack Size: 10 Pcs

Folinic Acid (Calcium folinate)

  1. Colorectal Cancer: Used as an adjunct to fluorouracil for chemotherapy treatment.
  2. Methotrexate Toxicity: Acts as an antidote for the toxicity caused by methotrexate.
  3. Folate-Deficient Megaloblastic Anaemia: To treat folate deficiency-related anemia.

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✅ Description:

Folinic acid (calcium folinate) enters cells as 5-methyl tetrahydrofolate, providing the necessary cofactor that is blocked by methotrexate.

  • It stabilizes the binding of 5-dUMP to thymidylate synthetase and enhances the activity of fluorouracil.
  • It neutralizes the toxic effects of methotrexate while increasing the efficacy of fluorouracil.
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✔️ Dosage & Administration

For Adults:

Oral Antidote for Methotrexate Toxicity:

  • 15 mg every 6 hours for 10 doses, starting 24 hours after methotrexate infusion.
  • Continue until serum methotrexate levels are <0.05 micromolar.
  • Can be administered via IM/IV injection as an alternative.

For Folate-Deficient Megaloblastic Anaemia:

  • 15 mg daily (oral route).

Adjunct to Fluorouracil in Colorectal Cancer:

  • 200 mg/m² Body Surface Area (BSA) via slow IV injection over at least 3 minutes, followed by 370 mg/m² fluorouracil by IV injection.
  • Treatment is given for 5 consecutive days and repeated every 28 days for 2 courses.
  • Subsequent doses may be repeated every 4-5 weeks if the patient has recovered from the toxic effects.

Intramuscular Folate-Deficient Megaloblastic Anaemia:

  • Up to 1 mg/day.

Always follow a healthcare professional’s advice for accurate dosing.

✔️ Side Effects

Common:

  • Allergic reactions (e.g., rash, pruritus, erythema, urticaria).
  • Nausea, vomiting, fever.

Serious:

  • Rare side effects like severe enterocolitis, diarrhea, and dehydration (especially in elderly patients).
✔️ Drug Interactions
  1. Fluorouracil: Folinic acid may increase toxicity when given with fluorouracil.
  2. Sulfamethoxazole-Trimethoprim: Folinic acid can reduce its efficacy in treating pneumocystis carinii pneumonia.
  3. Other Interactions: Be cautious when combined with other medications such as methotrexate, warfarin, anticonvulsants, and antibiotics.
✔️ Contraindications
  1. Hypersensitivity to folinic acid or any component of the product.
  2. Pernicious anemia or any other megaloblastic anemia caused by vitamin B12 deficiency.
  3. Intrathecal or intraventricular administration.
✔️ Precautions
  1. Undiagnosed Megaloblastic Anaemia: Ensure diagnosis of megaloblastic anemia before use.
  2. Folate-Dependent Tumors: Exercise caution.
  3. Pregnancy: Use only if the potential benefit justifies the risk to the fetus.
  4. Monitor Serum Methotrexate Levels: Essential for determining optimal dose and duration.
  5. Monitor Electrolytes and Liver Function: Regular testing is advised.
✔️ Storage Conditions
  • Store below 30°C.
  • Keep away from light and moisture.
  • Keep out of reach of children.
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Check our pricing section for Folinex 15mg Tablet price in Bangladesh. After Submitting Order, You may receive phone call for verification, price and delivery confirmation. We deliver inside/outside Dhaka (Delivery all over Bangladesh). We offer express/urgent medicine delivery inside Dhaka. Do not forget to check discount/cashback offers if you are eligible to avail any.

⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.

📦Pricing Information, Availability:
Product Availability & Pricing Notice Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.

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