Calcium Folinate Hydrate (Folinic Acid): Active metabolite of folic acid.
Each tablet contains:
Folinic Acid is a calcium salt of tetrahydrofolic acid (a metabolite of folic acid). It is a cofactor in purine and pyrimidine biosynthesis, essential for DNA and RNA synthesis. Acts as an antidote to folic acid antagonists (e.g., methotrexate) by "rescuing" normal cells from toxicity. Folinic acid does not interfere with the antibacterial activity of folate antagonists like trimethoprim.
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Folinic Acid/Folix is indicated for:
Neutralizing Toxic Effects of Folic Acid Antagonists:
Calcium Folinate Rescue Therapy:
Treatment of Megaloblastic Anemia:
Calcium folinate (Folinic Acid) is the calcium salt of tetrahydrofolic acid, a metabolite and active form of folic acid. It serves as a cofactor for 1-carbon transfer reactions in the synthesis of purines and pyrimidines, which are crucial for DNA and RNA production.
Mechanism of Action:
Interaction with 5-FU:
Selective Rescue:
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