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Gefinix 250mg Tablet 10pcs
- Gefitinib inhibits the ATP-binding site of the EGFR tyrosine kinase, preventing the activation of the Ras signal transduction cascade.
- This inhibition suppresses malignant cell growth and proliferation.
- EGFR is commonly overexpressed in cancers like lung and breast cancer, driving uncontrolled cell growth.
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✅ Description:
- Gefinix 250 is used for the treatment of non-small cell lung cancer (NSCLC):
- Specifically in patients with metastatic cancer.
- Those with abnormal epidermal growth factor receptor (EGFR) genes.
- Patients who have not received prior cancer treatment.
- Can be taken with or without food, ideally at the same time daily, and continued as prescribed by a doctor.
Relevant Products / প্রাসঙ্গিক পণ্য
✔️ Uses
- Non-small cell lung cancer
✔️ Reported adverse effects in NSCLC trials include:
- Common: Nausea (18%), asthenia (17%), pyrexia (9%), alopecia (4.7%).
- Less Common: Hemorrhage (4.3%), dry mouth (2%), dehydration (1.8%), allergic reactions (1.1%), elevated blood creatinine (1.5%), pancreatitis (0.1%).
✔️ How does
Gefinix 250 works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
✔️ Dosage & Administration
- Recommended Dose: 250 mg orally once daily, with or without food.
- Treatment is continued until disease progression or unacceptable toxicity.
- If a dose is missed, do not take it within 12 hours of the next scheduled dose.
✔️ Drug Interactions
- CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine) can reduce Gefitinib levels.
- CYP3A4 inhibitors (e.g., itraconazole, ketoconazole) can increase plasma concentrations.
- Warfarin: May increase INR or bleeding risk.
- Metoprolol: May have elevated blood levels when co-administered.
- Vinorelbine: Gefitinib may exacerbate neutropenia caused by Vinorelbine.
- Gastric pH-altering agents (e.g., PPIs, H2 antagonists) can reduce Gefitinib efficacy.
✔️ Contraindications
- Hypersensitivity to Gefitinib or its components.
- Lactation: Not recommended due to unknown excretion in breast milk.
✔️ Pregnancy & Lactation
- Pregnancy Category D:
- Evidence shows potential fetal harm.
- Use only if benefits outweigh risks (e.g., in life-threatening situations or where alternative treatments are ineffective).
- Lactation: Not recommended due to unknown excretion in breast milk.
✔️ Use with caution in
- Patients with idiopathic pulmonary fibrosis or new/worsening pulmonary or eye symptoms.
- Renal and hepatic dysfunction.
- Pregnant women.
- Monitoring Parameters:
- Liver function tests.
- Prothrombin time (PT) and INR.
✔️ Storage
- Store at 20-25°C in a cool, dry place.
- Keep out of the reach of children.
Disclaimer:
ePharma sole intention is to ensure that its consumers get proper
information as musch as possible. Although we do not guarantee the
accuracy and the completeness of the information that provided and
here information is for informational purposes only.
The information contained herein should NOT be used as a substitute
for the advice of a qualified physician. This may not cover
everything about particular health conditions,
lab tests, medicines, all possible side effects, drug interactions,
warnings, alerts, etc. Please consult your healthcare professional
and discuss all your queries related to any disease or medicine. We
intend to support, not replace, the doctor-patient relationship.
