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Gefinix 250mg Tablet 10pcs
- Gefitinib inhibits the ATP-binding site of the EGFR tyrosine kinase, preventing the activation of the Ras signal transduction cascade.
- This inhibition suppresses malignant cell growth and proliferation.
- EGFR is commonly overexpressed in cancers like lung and breast cancer, driving uncontrolled cell growth.
Discount
Price: ৳ 2,450
MRP:
৳
2500
2%
Off
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Cash on Delivery - All over Bangladesh
Regular Delivery - 8-12 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
✅ Description:
- Gefinix 250 is used for the treatment of non-small cell lung cancer (NSCLC):
- Specifically in patients with metastatic cancer.
- Those with abnormal epidermal growth factor receptor (EGFR) genes.
- Patients who have not received prior cancer treatment.
- Can be taken with or without food, ideally at the same time daily, and continued as prescribed by a doctor.
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✔️ Uses
- Non-small cell lung cancer
✔️ Reported adverse effects in NSCLC trials include:
- Common: Nausea (18%), asthenia (17%), pyrexia (9%), alopecia (4.7%).
- Less Common: Hemorrhage (4.3%), dry mouth (2%), dehydration (1.8%), allergic reactions (1.1%), elevated blood creatinine (1.5%), pancreatitis (0.1%).
✔️ How does
Gefinix 250 works by blocking the action of the abnormal protein that signals cancer cells to multiply. This helps to stop or slow the spread of cancer cells.
✔️ Dosage & Administration
- Recommended Dose: 250 mg orally once daily, with or without food.
- Treatment is continued until disease progression or unacceptable toxicity.
- If a dose is missed, do not take it within 12 hours of the next scheduled dose.
✔️ Drug Interactions
- CYP3A4 inducers (e.g., rifampicin, phenytoin, carbamazepine) can reduce Gefitinib levels.
- CYP3A4 inhibitors (e.g., itraconazole, ketoconazole) can increase plasma concentrations.
- Warfarin: May increase INR or bleeding risk.
- Metoprolol: May have elevated blood levels when co-administered.
- Vinorelbine: Gefitinib may exacerbate neutropenia caused by Vinorelbine.
- Gastric pH-altering agents (e.g., PPIs, H2 antagonists) can reduce Gefitinib efficacy.
✔️ Contraindications
- Hypersensitivity to Gefitinib or its components.
- Lactation: Not recommended due to unknown excretion in breast milk.
✔️ Pregnancy & Lactation
- Pregnancy Category D:
- Evidence shows potential fetal harm.
- Use only if benefits outweigh risks (e.g., in life-threatening situations or where alternative treatments are ineffective).
- Lactation: Not recommended due to unknown excretion in breast milk.
✔️ Use with caution in
- Patients with idiopathic pulmonary fibrosis or new/worsening pulmonary or eye symptoms.
- Renal and hepatic dysfunction.
- Pregnant women.
- Monitoring Parameters:
- Liver function tests.
- Prothrombin time (PT) and INR.
✔️ Storage
- Store at 20-25°C in a cool, dry place.
- Keep out of the reach of children.
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Product Availability & Pricing Notice
Please note that pricing, availability, and service offerings are subject to change due to: Market fluctuations, Manufacturer or supplier adjustments, Product discontinuation or temporary unavailability, Advertising errors. All orders depend on stock availability and staff resources. If services are provided on a time-and-materials basis, any shared estimates are for planning purposes only.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
