Gistol 160mg Tablet 10pcs

✔️ Uses of Gistol 160mg Tablet

• Anorexia Nervosa
• Cachexia
• Breast cancer
• Endometrial cancer
• Unexplained Weight Loss

✔️ How does Gistol 160mg Tablet work?

Gistol works by changing the hormone balance in the body which results in interference of growth in hormone-dependent cancer cells which leads to inhibition of growth and spread of cancer cells.

✔️ Side Effects of Gistol 160mg Tablet

• Common: Weight gain, increased appetite.
• Serious: Thromboembolic events (e.g., thrombophlebitis, pulmonary embolism), glucocorticoid effects (e.g., new-onset diabetes, Cushing's syndrome, adrenal insufficiency).
• Other: Nausea, dyspnea, tumor flare, hyperglycemia, alopecia, hypertension, mood changes, hot flashes.

✔️ Quick Suggestions:

• Gistol 160 is used to treat women with certain hormone-dependent cancers such as breast cancer and endometrial cancer.
• It may also be used for treating appetite and weight loss in people with advanced cancer or AIDS.
• You may have to take it for at least 2 months before you notice any changes in your appetite.
• Your doctor might do regular blood tests to check your hormones and blood sugar levels while you are taking this medicine.
• Do not take Gistol 160 if you are pregnant or breastfeeding.
• Inform your doctor immediately if you notice unexplained swelling and pain in your limbs, shortness of breath, chest pain, severe headache, or vision changes. These could be symptoms of a blood clot in a vein.
• Do not stop taking the medicine suddenly without talking to your doctor first.

✔️ Indication of Gistol 160mg Tablet

Megestrol is used in breast cancer and endometrial cancer. It specifically helps treat breast and endometrial cancer that are hormone-dependent. It may also be used for treating low appetite and weight loss in patients with advanced cancer or HIV.

✔️ How to take Gistol 160mg Tablet

Take Gistol 160mg Tablet as advised by your physician. Swallow the medicine with a glass of water. Do not crush or chew the medicine. Your doctor will decide the correct dose and duration for you depending on your age, body weight, and disease condition. No serious side effects have been reported with doses up to 1600 mg/day.

✔️ Pharmacology

Megestrol Acetate is a synthetic progestogen with antineoplastic properties. Its exact mechanism is not fully understood but involves inhibition of pituitary gonadotropin production and reduction of estrogen secretion, potentially affecting hormone-dependent tumors. Peak plasma concentrations are reached 2-3 hours after oral administration, with a half-life of 33-38 hours. It is excreted primarily through urine (66%) and feces (20%).

✔️ Dosage & Administration of Gistol 160mg Tablet

Gistol Tablets:

• Breast Cancer: 160 mg/day.
• Endometrial Carcinoma: 40-320 mg/day in divided doses.
• Treatment should continue for at least 2 months to evaluate effectiveness.

Pediatric: Safety and effectiveness have not been established.

Geriatric: Limited data for patients 65 years and older; response compared to younger patients is unclear.

✔️ Interaction

Inform your doctor if you are taking any medicines including prescription, non-prescription, over-the-counter medicines, vitamins, and/or herbal supplements before taking this medicine.

✔️ Contraindications

• History of hypersensitivity to Megestrol Acetate or its components.
• Known or suspected pregnancy.

✔️ Pregnancy & Lactation

• Pregnancy: Category D; not recommended during the first four months of pregnancy.
• Lactation: Small amounts are excreted in breast milk; nursing should be discontinued during treatment.

✔️ Precautions & Warnings

• Close monitoring is required for patients treated for recurrent or metastatic cancer.
• Use cautiously in patients with a history of thromboembolic disease or diabetes (increased insulin requirements have been reported).

✔️ Storage:

Store below 30°C in a cool, dry place, away from light and moisture. Keep out of reach of children.