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Hepanib 200mg Tablet (Pot)
Hepanib (Sorafenib):
- Hepatocellular Carcinoma (HCC): For patients with unresectable HCC.
- Renal Cell Carcinoma (RCC): For patients with advanced RCC.
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✅ Description:
Sorafenib inhibits tumor cell proliferation by targeting multiple kinases, including RAF kinases (CRAF, BRAF), receptor tyrosine kinases (VEGFR-1, VEGFR-2, VEGFR-3, PDGFR-β), and others involved in angiogenesis and tumor growth.
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✔️ Adverse Effects
- Serious: Cardiac ischemia/infarction, hemorrhage, hypertension, gastrointestinal perforation, dermatologic toxicity (e.g., hand-foot syndrome).
- Common: Rash, diarrhea, fatigue.
✔️ Dosage & Administration
- Standard Dose: 400 mg twice daily without food (1 hour before or 2 hours after meals).
- Dose Reduction:
- 1st level: 400 mg once daily.
- 2nd level: 400 mg every other day.
- Missed Dose: Skip the missed dose and take the next dose at the regular time.
- Pregnancy: May cause fetal harm; avoid use.
- Lactation: Not recommended during therapy and for 1 month after.
- Pediatrics: Safety not established.
- Hepatic/Renal Impairment:
- No dose adjustment for renal impairment.
- Mild to moderate hepatic impairment: Plasma concentrations may be reduced.
Adverse Event Management: Adjustments or discontinuations based on toxicity grades (e.g., hand-foot syndrome).
✔️ Key Drug Interactions
- UGT1A1 & UGT1A9 Substrates: Increased exposure to these substrates.
- Docetaxel & Doxorubicin: Increased plasma concentrations when co-administered.
- CYP3A4 Inducers: Reduced Sorafenib levels (e.g., Rifampicin, St. John’s Wort).
- Neomycin: Reduces Sorafenib exposure by ~54%.
- Warfarin: Monitor for changes in INR or bleeding.
✔️ Contraindications
- Severe hypersensitivity to Sorafenib or its components.
- Use in combination with carboplatin and paclitaxel in patients with squamous cell lung cancer due to increased mortality.
✔️ Precautions & Warnings
- Monitor for bleeding risks, especially in patients taking anticoagulants.
- Adjust therapy for hypertension or cardiac ischemia/infarction.
- Temporarily withhold for wound healing post-surgery.
✔️ Storage
- Store below 30°C.
- Keep in the original bottle with desiccant.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
