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Ibrutinib is used for the treatment of blood cancers like mantle cell lymphoma, chronic lymphocytic leukemia (CLL), and lymphoplasmacytic lymphoma.
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✅ Description:
Ibrucent 140mg Capsule is employed for the treatment of various conditions:
- Chronic Lymphocytic Leukemia: Used to treat chronic lymphocytic leukemia, a type of blood cancer affecting lymphocytes.
- Mantle Cell Lymphoma: Administered to individuals with mantle cell lymphoma, a lymph node cancer, who haven't responded well to prior therapy.
- Waldenstrom's Macroglobulinemia: Used in the treatment of Waldenstrom's macroglobulinemia, a cancer originating from bone marrow lymphocytes, for patients with inadequate response to previous therapy.
- Marginal Zone Lymphoma: Prescribed for marginal zone lymphoma patients who have undergone specific chemotherapy and still require treatment.
- Chronic Graft-Versus-Host Disease (cGVHD): Utilized to address chronic graft-versus-host disease in patients who haven't responded sufficiently to prior systemic therapies.
Safety Advices
Alcohol
UNSAFE
There is limited information on the interaction of Ibrucent 140mg Capsule with alcohol.
Pregnancy
UNSAFE
Due to limited information about its safety during pregnancy, Ibrucent 140mg Capsule is not recommended for use by pregnant women to avoid potential risks to the developing fetus.
Breastfeeding
UNSAFE
There's no available information on whether Ibrucent 140mg Capsule passes into breast milk. Breastfeeding women are advised not to use this medication.
Driving
CAUTION
Ibrucent 140mg Capsule might have a slight impact on driving ability. If you experience dizziness or weakness after taking the medicine, it's recommended to avoid driving.
Kidney
CONSULT YOUR DOCTOR
Patients with kidney diseases should use Ibrucent 140mg Capsule with caution due to the increased risk of worsening their condition. Close monitoring of kidney function and potential dose adjustments might be necessary based on the patient's clinical situation.
Liver
Patients with liver diseases should also use Ibrucent 140mg Capsule with caution, as it could worsen their condition. Regular monitoring of liver function is important, and dose adjustments or alternative treatments might be required based on the patient's clinical condition.
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✔️ Uses of Ibrucent 140mg Capsule
- Mantle-Cell Lymphoma
- Blood cancer (Chronic lymphocytic leukemia)
✔️ How does Ibrucent 140mg Capsule work?
Ibrucent 140mg Capsule works by inhibiting the actions of certain abnormal proteins that cause the cancer cells to multiply. This helps in stopping the growth and spread of cancer.
✔️ Side Effects of Ibrucent 140mg Capsule
Possible adverse reactions include bleeding, infections, atrial fibrillation, hypertension, and more. Diarrhea and visual disturbances are also noted.
✔️ Quick Suggestions:
- Take Ibrucent 140mg Capsule at the same time every day, either with or without food.
- It is advisable to stay hydrated and drink plenty of fluids while taking this medication.
- Do not skip any dose and complete the course as suggested by your doctor.
- Use an effective method of birth control to avoid pregnancy while taking this medication.
- Your doctor may get regular blood tests done to monitor your liver function and blood cell count in your blood.
✔️ Indication
Ibrutinib is prescribed for various conditions:
- Mantle Cell Lymphoma (MCL) with prior therapy.
- Chronic lymphocytic leukemia and small lymphocytic lymphoma.
- Chronic lymphocytic leukemia with 17p deletion.
- Waldenstrom Macroglobulinemia (WM).
- Marginal zone lymphoma (MZL) requiring systemic therapy after anti-CD 20-based treatment.
✔️ Pharmacology
Ibrutinib, a BTK inhibitor, disrupts B-cell antigen receptor and cytokine receptor pathways. This inhibits malignant B-cell growth, survival, and migration.
✔️ Dosage & Administration of Ibrucent 140mg Capsule
For MCL and MZL: 560 mg daily until disease progression or unacceptable toxicity. For CLL/SLL and WM: 420 mg daily until disease progression or unacceptable toxicity. In combination with bendamustine and rituximab: 420 mg daily.
Administration
Take orally daily at a consistent time, swallowing capsules whole with water.
✔️ Interaction
Ibrutinib may interact with certain medications like ketoconazole, clarithromycin, and others. Consult your doctor regarding potential interactions.
✔️ Contraindications
Avoid if hypersensitive to active ingredients or excipients.
✔️ Pregnancy & Lactation
Ibrutinib can harm a developing fetus. Pregnant or breastfeeding individuals should avoid it.
✔️ Precautions & Warnings
Make sure to discuss with your doctor if:
- You've experienced unusual bruising or bleeding, or if you're taking medications or supplements that increase bleeding risk (like warfarin).
- You've had or currently have an irregular heartbeat, heart failure, or symptoms like weakness, dizziness, fainting, or swollen legs.
- You have liver or kidney problems.
- You have high blood pressure.
- You've recently undergone surgery or have surgery scheduled.
- You notice symptoms such as trouble thinking, difficulty walking, vision issues, limb weakness, headache, or trouble speaking after taking this medicine.
- You feel pain in the upper left belly, below the left rib, or at the tip of your left shoulder after discontinuing this medicine.
- You experience signs of infection like fever, chills, body pain, fatigue, or yellowing of the skin or eyes.
✔️ Storage Conditions
Store below 30°C, away from light, and out of children's reach.
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here information is for informational purposes only.
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