Megestrol Acetate is a synthetic drug with antineoplastic and progestational properties. Although the exact mechanism of its antineoplastic effects on endometrial carcinoma remains unclear, it is believed to involve pituitary gonadotrophin suppression, leading to reduced estrogen secretion.
In treating breast cancer, megestrol acetate works by altering the effects of other steroid hormones and directly affecting tumor cells. Hormone receptors in metastatic cancer may vary across tissues. The drug inhibits estrogen-driven gene transcription and cell function alterations. At pharmacologic doses, it reduces hormone-dependent cancer cells and negates estrogen’s stimulatory effects.
Megestrol Acetate achieves peak plasma levels 2 to 3 hours after a single 160 mg oral dose, with a plasma half-life of 33 to 38 hours. Approximately 66% of the dose is excreted in urine, and about 20% is eliminated via feces.
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Mezoxia tablets are prescribed for the palliative treatment of advanced breast or endometrial carcinoma, including recurrent, inoperable, or metastatic conditions. This medication should not replace established treatments such as surgery, radiation, or chemotherapy.
Alcohol consumption may increase the risk of side effects and worsen the disease. So, avoid alcohol consumption while using Mezoxia Tablet.
Mezoxia Tablet is generally not recommended for use during pregnancy and in women planning for pregnancy. Consult your doctor before taking the medicine.
Mezoxia Tablet is not generally recommended for use in breastfeeding women. Consult your doctor before taking the medicine.
Mezoxia Tablet is unlikely to affect your ability to drive/operate machines. Consult your doctor before taking the Mezoxia Tablet.
Mezoxia Tablets should be used with caution in patients with kidney problems such as chronic kidney disease. Consult your doctor before taking Mezoxia Tablet
Mezoxia Tablets should be used with caution in patients with severe liver problems. Consult your doctor before taking MEGAHENZ 40MG TABLET
No severe or unexpected adverse effects have been reported in studies using doses as high as 1600 mg/day.
Inform your doctor if you are taking any medicines including prescription, non-prescription, over-the-counter medicines, vitamins, and/or herbal supplements before taking this medicine.
Safety and efficacy have not been established.
Limited data exist to determine whether elderly patients respond differently than younger ones
Store below 30°C in a cool, dry place, protected from light and moisture. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.