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Neoclomide 50mg Tablet 10pcs
Cyclophosphamide undergoes biotransformation in the liver, where it is converted into active alkylating metabolites by a mixed-function microsomal oxidase system. These metabolites inhibit the growth of rapidly dividing malignant cells by cross-linking tumor cell DNA.
Cyclophosphamide is well absorbed orally, with a bioavailability exceeding 75%. Following intravenous administration, peak plasma concentrations of metabolites occur within 2 to 3 hours. The elimination half-life of the unchanged drug ranges from 3 to 12 hours. Excretion primarily occurs via metabolites, with 5-25% of the dose eliminated as an unchanged drug in urine. Some metabolites bind to plasma proteins (>60%). No single metabolite has been identified as solely responsible for therapeutic or toxic effects.
While elevated metabolite levels have been observed in patients with renal impairment, there is no consistent evidence of increased clinical toxicity.
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✅ Description:
Neoclomide, while effective as a standalone treatment for certain malignancies, is more commonly administered in combination or sequence with other antineoplastic drugs. It is often used in the treatment of the following conditions:
- Malignant Lymphomas (Stages III and IV, Ann Arbor staging system): Hodgkin’s disease, lymphocytic lymphoma (nodular or diffuse), mixed-cell type lymphoma, histiocytic lymphoma, Burkitt’s lymphoma.
- Multiple Myeloma
- Leukemias: Chronic lymphocytic leukemia, chronic granulocytic leukemia (not effective in acute blastic crisis), acute myelogenous and monocytic leukemia, and acute lymphoblastic (stem-cell) leukemia in children (effective in prolonging remission).
- Mycosis fungoides: Advanced stages of the disease.
- Neuroblastoma: Disseminated disease.
- Adenocarcinoma of the Ovary
- Retinoblastoma
- Carcinoma of the Breast
Nonmalignant Disease:
In children, Neoclomide can be used to treat biopsy-proven "minimal change" nephrotic syndrome when corticosteroid therapy fails to produce adequate results or causes intolerable side effects. However, it should not be considered first-line therapy and is not indicated for nephrotic syndrome in adults or other renal conditions.
Use only as directed by a registered physician.
Side Effects
- Digestive System: Commonly causes nausea and vomiting. Less frequent effects include anorexia, abdominal discomfort, diarrhea, hemorrhagic colitis, oral ulcers, and jaundice. These effects typically resolve upon discontinuation of treatment.
- Skin: Alopecia is common, with hair regrowth during or after treatment, sometimes with altered texture or color. Rash, pigmentation changes, and nail alterations can occur. Rarely, Stevens-Johnson syndrome and toxic epidermal necrolysis have been reported.
- Hematopoietic System: Leukopenia is common and dose-dependent, with reductions below 2000 cells/mm³ associated with increased infection risk. Thrombocytopenia and anemia occur occasionally and are reversible upon dosage adjustment or treatment cessation.
- Urinary System: Hemorrhagic ureteritis and renal tubular necrosis have been reported, usually resolving after discontinuation of therapy.
- Respiratory System: Rare cases of interstitial pneumonitis and pulmonary fibrosis have been noted with prolonged high-dose use.
Other: Anaphylaxis, SIADH (syndrome of inappropriate antidiuretic hormone secretion), malaise, and asthenia have been reported.
- Pregnancy: Category D. Cyclophosphamide is excreted in breast milk and may cause adverse effects and tumorigenicity in infants. Nursing should be discontinued during treatment, or the drug should be stopped if breastfeeding is essential.
Similar Products
✔️ Neoclomide 50 Tablet is primarily used to treat various malignant diseases, including:
- Lymphomas: Hodgkin’s disease, mixed-cell type lymphoma, lymphocytic lymphoma, histiocytic lymphoma.
- Multiple Myeloma
- Burkitt’s Lymphoma
- Mycosis Fungoides
- Leukemias
- Cancers: Nerve tissue cancer, eye cancer (retinoblastoma), ovarian cancer, soft tissue cancer, bone cancer, and breast cancer.
- Nonmalignant Disease: Minimal change nephrotic syndrome in children.
✔️ Uses of Neoclomide 50
Treats Cancer and nephrotic syndrome (kidney disease).
✔️ How does Neoclomide 50 work?
Neoclomide 50 Tablet contains Cyclophosphamide, an alkylating agent. It damages the DNA of cancer cells, preventing their growth and multiplication. By interfering with the genetic material, Neoclomide 50 Tablet effectively kills cancer cells and slows tumor progression.
✔️ Side Effects: Neoclomide 50
Some common side effects include:
- Fever
- Nausea and vomiting
- Diarrhea
- Hair loss
- Low blood cell count (leukopenia, anemia)
- Abdominal pain
If any of these side effects persist or worsen, consult your doctor immediately.
✔️ Quick Suggestions:
- Take Neoclomide 50 with food if you experience irritation of the stomach, preferably in the morning.
- Your doctor may get regular blood tests to monitor your blood counts while on treatment with this medication.
- You are more likely to get sick or heal slower while taking this medication. Talk to your doctor before getting any vaccines.
- Contact your doctor immediately if you experience difficulty in urinating or blood in urine while on treatment with this medication.
- Do not take Neoclomide 50 if you are pregnant or breastfeeding.
✔️ Dosage & Administration of Neoclomide 50
Malignant Diseases (Adults and Children):
- Intravenous Regimens:
- 40-50 mg/kg divided over 2-5 days.
- 10-15 mg/kg every 7-10 days.
- 3-5 mg/kg twice weekly.
- Oral Regimens: 1-5 mg/kg/day for initial or maintenance therapy.
Dosages should be adjusted based on tumor response and leukocyte counts. Leukocyte counts as low as 2000 cells/mm³ (short courses) or 3000 cells/mm³ (prolonged therapy) are tolerable if granulocytopenia is not severe.
When used in combination with other cytotoxic drugs, cyclophosphamide dosages may need to be reduced. Dialysis can remove cyclophosphamide and its metabolites. However, there is no clear evidence supporting dose adjustments in patients with renal impairment.
Nonmalignant Diseases (Minimal Change Nephrotic Syndrome in Children):
- 2.5-3 mg/kg orally daily for 60-90 days.
- Extended treatment beyond 60 days increases the risk of oligospermia and azoospermia, with sterility more likely after 90 days. Corticosteroid therapy may be tapered during cyclophosphamide treatment.
Use only as directed by a registered physician.
- Pediatric Patients: The safety profile is similar to that of adults.
- Geriatric Patients: Older patients may be more susceptible to Neoclomide-related toxicities. Dosages should start at the lower end of the range and be adjusted based on response.
Take Neoclomide 50 Tablet as prescribed by your doctor, based on your medical condition and response to therapy. It is important to follow the prescribed dosage and not discontinue the medication unless advised by your physician.
✔️ Interaction
- Chronic high-dose phenobarbital increases the metabolism and leukopenic activity of Neoclomide.
- Neoclomide inhibits cholinesterase activity, enhancing the effects of succinylcholine chloride. Anesthesiologists should be informed if a patient has received Neoclomide within 10 days of general anesthesia.
✔️ Contraindications:
- Do not take Neoclomide 50 if you are allergic to cyclophosphamide or any other components of the medication.
- Avoid Neoclomide 50 if you have a bladder obstruction or other urination problems.
✔️ Pregnancy & Lactation
Neoclomide 50 should not be used during pregnancy or while breastfeeding due to potential harm to the baby.
✔️ Precautions & Warnings
- Neoclomide 50 may cause dizziness; avoid driving or operating machinery unless you feel alert.
- Neoclomide 50 should only be given to children if prescribed by a doctor.
- Let your doctor know about any existing health conditions or ongoing medications to prevent potential drug interactions or side effects.
✔️ Storage:
Store below 25°C in a dry location, protected from light and moisture. Do not freeze. Keep out of reach of children.
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