Palbociclib inhibits Cyclin-dependent kinases (CDK) 4 and 6, which are key regulators of cellular proliferation. It works by:
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Palbokin is a kinase inhibitor used to treat hormone receptor (HR)-positive, human epidermal growth factor receptor 2 (HER2)-negative advanced or metastatic breast cancer. It is prescribed in combination with:
Palbociclib selectively and reversibly inhibits cyclin-dependent kinases (CDK) 4 and 6. These kinases, along with cyclin D1, play a role in cell proliferation by regulating the cell cycle progression from the G1 to S phase. Inhibiting CDK4/6 slows the proliferation of breast cancer cells.
Note: Not approved for use in children.
Agents That Increase Palbokin Plasma Levels:
Agents That Decrease Palbokin Plasma Levels:
Drugs Affected by Palbokin:
Keep below 30°C temperature, away from light & moisture. Keep out of the reach of children.
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