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PegNeufil SC Injection
Pegfilgrastim, the active ingredient in PegNeufil, is a pegylated Granulocyte Colony-Stimulating Factor (G-CSF). It stimulates the production and release of functional neutrophils from the bone marrow. Pegfilgrastim is a covalent conjugate of recombinant human G-CSF (Filgrastim) and polyethylene glycol. It has a molecular weight of approximately 39 kD. The pegylation increases its half-life and efficacy, making it suitable for single-dose administration per chemotherapy cycle.
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✅ Description:
PegNeufil is a leukocyte growth factor used to reduce the risk of infection, as indicated by febrile neutropenia, in patients with non-myeloid malignancies undergoing myelosuppressive chemotherapy associated with a significant risk of febrile neutropenia.
✔️ Dosage & Administration of PegNeufil 6mg/0.6ml
- A single subcutaneous injection of 6 mg per chemotherapy cycle for adults.
- Do not administer PegNeufil 14 days before or 24 hours after chemotherapy.
- Inspect the solution for discoloration or particulate matter. Do not use if abnormalities are observed.
- The needle cover contains dry natural rubber (latex); avoid it in individuals with latex allergies.
Pediatric Use:
- Safety and efficacy in children have not been established.
Geriatric Use:
- No significant differences in safety or effectiveness between older adults (65+ years) and younger patients were observed in clinical studies.
Renal Impairment:
- No dosage adjustment is needed in patients with renal dysfunction, including end-stage renal disease.
✔️ Overdose Effects of PegNeufil 6mg/0.6ml
- The maximum safe dosage is not determined.
- Single doses of up to 300 mcg/kg have been administered without serious effects. Observed effects include increased Absolute Neutrophil Count (ANC) and White Blood Cell (WBC) counts.
✔️ Serious Risks:
Splenic Rupture:
- Fatal splenic rupture has been reported. Evaluate for an enlarged spleen or splenic rupture in patients experiencing left upper abdominal or shoulder pain.
Acute Respiratory Distress Syndrome (ARDS):
- This may occur in patients receiving PegNeufil. Monitor for fever, lung infiltrates, or respiratory distress. Discontinue PegNeufil in patients with ARDS.
Serious Allergic Reactions:
- Including anaphylaxis, which may recur after the initial reaction subsides. Permanently discontinue PegNeufil in such cases.
Sickle Cell Crisis:
- Severe and potentially fatal sickle cell crises have occurred in patients with sickle cell disorders receiving Pegfilgrastim or Filgrastim.
✔️ Drug Interactions
- No formal studies have been conducted on drug interactions with PegNeufil.
- Bone-imaging changes: Increased hematopoietic activity due to PegNeufil may transiently affect bone-imaging results. Consider this when interpreting scans.
- Mixing: Do not mix PegNeufil with other medicinal products, especially sodium chloride solutions.
✔️ PegNeufil is contraindicated in patients with:
- A history of severe allergic reactions to Pegfilgrastim or Filgrastim.
✔️ Pregnancy & Lactation
Pregnancy (Category C):
- Animal studies indicate potential harm to the fetus. Use only if the potential benefit outweighs the risk.
Lactation:
- It is not known if PegNeufil is secreted in human milk. Caution is advised when administering to nursing women.
✔️ Storage Conditions
- Store at 2–8°C (refrigerated).
- Do not freeze or shake.
- Protect from light. Keep out of reach of children.
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