Fedrin is used to treat low blood pressure following spinal anesthesia. It works by narrowing blood vessels, thereby increasing blood flow to the heart and lungs. This medication should be administered under a doctor's supervision, and the dose and duration will be determined by your doctor.
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Ephedrine Hydrochloride
It's unclear whether consuming alcohol with Fedrin is safe. Please consult your doctor.
Fedrin may not be safe to use during pregnancy. Limited human studies suggest potential harm to the developing baby. Consult your doctor to weigh the benefits and risks before use.
Fedrin is likely unsafe during breastfeeding as it may pass into breast milk and harm the baby. Consult your doctor.
Fedrin typically doesn't affect your ability to drive.
There is limited information available on the use of Fedrin in patients with kidney disease. Please consult your doctor.
There is limited information available on the use of Fedrin in patients with Liver disease. Please consult your doctor.
Treatment of hypotension following spinal anesthesia.
Fedrin acts on blood vessels, improving blood flow to the heart and lungs.
Common side effects include gastrointestinal disorders, cardiac disorders, nervous system disorders, and psychiatric disorders. Potentially fatal effects may occur in cases of hypersensitivity or overdose.
Fedrin is indicated to reverse hypotension induced by spinal or epidural anesthesia. It is not effective in hypotensive crises due to shock, circulatory collapse, or hemorrhage.
Ephedrine, the active ingredient in Fedrin, is a stimulant drug classified as a sympathomimetic. It acts as both an alpha and beta-adrenergic agonist and enhances the release of norepinephrine, a potent alpha agonist. Its effects are similar to those of the body's primary adrenergic hormone, adrenaline. Ephedrine increases central nervous system activity and stimulates other target cells.
To reverse hypotension induced by spinal or epidural anesthesia, administer 3 to 6 mg (maximum 9 mg) of Ephedrine Hydrochloride by slow intravenous injection, repeated every 3 to 4 minutes as needed. The maximum total dose is 30 mg. Ephedrine can also be administered intramuscularly or subcutaneously.
Large doses of Fedrin may cause giddiness, headache, nausea, vomiting, sweating, palpitations, difficulty in micturition, tremors, anxiety, restlessness, and insomnia. Some patients may experience these symptoms even with the usual therapeutic dosage.
Fedrin may cause a hypertensive crisis in patients taking Monoamine Oxidase Inhibitors. Use with caution in patients undergoing anesthesia with cyclopropane, halothane, or other volatile anesthetics. Increased risk of arrhythmias may occur in patients receiving cardiac glycosides, quinidine, or tricyclic antidepressants. There's also an increased risk of vasoconstrictor effects in patients receiving ergot alkaloids or oxytocin.
Ephedrine is contraindicated in coronary thrombosis and should be used with caution in patients with organic heart disease, hyperthyroidism, hypertension, and angina pectoris. Use caution in patients receiving digitalis.
Ephedrine is classified as Category C in pregnancy. It should be used only if the potential benefit justifies the potential risk to the fetus. Ephedrine is distributed into breast milk, so its use during lactation is not recommended due to the risk of adverse effects in the infant.
Use Fedrin with caution in patients with hyperthyroidism, diabetes mellitus, ischemic heart disease, hypertension, renal impairment, or angle-closure glaucoma. It may increase difficulty with micturition in patients with prostatic enlargement. Increased fetal heart rate and adverse effects in breast-fed infants have been reported.
Store Fedrin in a cool, dry place, protected from light. Keep it out of reach of children.
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