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Coughex 45mg Tablet 1 Strip
Coughex is used for the treatment of:
- Refractory chronic cough (persistent cough unresponsive to treatment).
- Unexplained chronic cough in adults.
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✅ Description:
- Gefapixant is a P2X3 receptor antagonist.
- Mechanism of action:
- P2X3 receptors are found in sensory C-fibers of the vagus nerve.
- Inflammation releases ATP, which binds to P2X3 receptors, triggering a cough reflex.
- Gefapixant blocks ATP-mediated activation, reducing chronic cough.
✔️ Dosage & Administration
- Adults: 45 mg tablet twice daily (with or without food).
- Missed dose: Skip the missed dose and take the next scheduled dose.
- Elderly: No dose adjustment required, but caution is advised due to potential renal impairment.
- Pediatric patients (<18 years): Safety and efficacy not established.
- Obstructive sleep apnea: Not recommended for patients with this condition.
- Liver disease: Not studied in hepatic impairment.
- Renal impairment:
- Severe impairment (eGFR <30 mL/min/1.73m², non-dialysis): 45 mg once daily.
- Mild to moderate impairment: No dose adjustment required.
🔹 Dizziness may occur – caution when driving or operating machines.
✔️ Side Effects
- Taste disturbances (dysgeusia, ageusia, hypogeusia).
- Upper respiratory infections.
- Reduced appetite.
- Dizziness, nausea, diarrhea, dry mouth, hypersalivation.
- Epigastric pain, dyspepsia, oral numbness (hypoesthesia), tingling (paresthesia).
✔️ Drug Interactions
- Proton pump inhibitors (e.g., Omeprazole): No significant interaction.
- CYP inhibition/induction potential: Low.
- No major drug interactions were identified.
✔️ Contraindications
Severe hypersensitivity reaction to Gefapixant or any ingredient.
✔️ Use in Pregnancy & Lactation
- Not recommended in pregnancy due to lack of data.
- Unknown if excreted in breast milk—avoid during breastfeeding.
- Fertility effects: No known impairment in humans, but animal studies show no adverse impact.
✔️ Precautions & Warnings
- Caution in patients with sulfonamide hypersensitivity.
- Do not discontinue without consulting a doctor.
✔️ Storage Conditions
- Store below 30°C in a cool, dry place.
- Keep away from light and out of children's reach.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
