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Gefapixant 45 mg | Indicated for Refractory or Unexplained Chronic Cough in Adults
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Regular Delivery - 12-24 Hours, Dhaka City*- Regular Delivery - 24-48 Hours, All Over Bangladesh*
ফ্রি ডেলিভারিঃ - ১৪৯৯ টাকা+ অর্ডারে, ঢাকা
শহরে- ফ্রি ডেলিভারিঃ - ৩৪৪৯ টাকা+ অর্ডারে, ঢাকার
বাহিরে
✅ Description:
Gefapix is prescribed for adult patients suffering from either refractory chronic cough or unexplained chronic cough when other underlying causes have been ruled out.
Gefapixant is a selective P2X3 receptor antagonist, which targets ATP-sensitive ion channels located on C-fibers of the vagus nerve in the respiratory tract. These fibers are activated during inflammation or chemical irritation, leading to the release of ATP, which triggers a cough reflex. By inhibiting ATP from binding to these receptors, Gefapixant reduces the cough signal and alleviates chronic coughing.
✔️ Adverse Effects
- Very Common: Taste-related disturbances such as dysgeusia, ageusia, and hypogeusia.
- Common: Upper respiratory infections, nausea, diarrhea, appetite loss, dizziness, dry mouth, oral numbness, increased salivation, stomach discomfort, and indigestion.
- Occasional: Urinary stones, nephrolithiasis.
✔️ Dosage & Administration
Adults: 45 mg tablet orally twice daily, with or without food.
Elderly: No dose adjustment is needed, but start cautiously due to possible reduced kidney function.
Pediatrics: Not recommended for use in patients under 18 years.
Renal Impairment:
Mild/Moderate (eGFR >30 mL/min/1.73m²): No adjustment needed.
Severe (eGFR <30 mL/min/1.73m², non-dialysis): Reduce to 45 mg once daily.
Hepatic Impairment: Not studied; caution is advised.
Obstructive Sleep Apnea: Not recommended for patients with chronic cough and concurrent sleep apnea.
Missed dose: If missed, skip and resume at the next scheduled dose.
✔️ Drug Interactions
Omeprazole (PPI): No significant effect on Gefapixant pharmacokinetics.
Gefapixant has low potential to interact with cytochrome P450 enzymes.
No clinically significant drug interactions reported.
✔️ Contraindications:
Known hypersensitivity to Gefapixant or its components.
✔️ Pregnancy & Lactation
Pregnancy: Not recommended due to insufficient human data.
Lactation: Unknown if excreted in breast milk; use with caution.
Fertility: No human data; animal studies show no adverse effects on fertility
✔️ Precautions & Warnings
- May cause dizziness, impacting the ability to drive or operate machinery.
- Avoid in patients with known sulfonamide hypersensitivity.
✔️ Storage:
Store in a cool, dry place below 30°C, protected from light. Keep out of reach of children.
⚠️Disclaimer:
At ePharma, we’re committed to providing accurate and accessible health information. However, all content is intended for informational purposes only and should not replace medical advice from a qualified physician. Please consult your healthcare provider for personalized guidance. We aim to support, not substitute, the doctor-patient relationship.
