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Mitaprex 15mg 10pcs
Mitaprex is indicated for the treatment of the major depressive disorder (MDD).
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✅ Description:
- Mirtazapine enhances central noradrenergic and serotonergic activity by antagonizing central presynaptic α2-adrenergic receptors.
- Acts as an antagonist at 5-HT2 and 5-HT3 receptors, reducing related side effects.
- Potent antagonist of histamine (H1) receptors, explaining its sedative effects.
- Moderate antagonist at peripheral α1-adrenergic and muscarinic receptors, contributing to orthostatic hypotension and mild anticholinergic side effects.
- Rapid and well-absorbed, with peak plasma levels in ~2 hours.
- Protein Binding: ~85%.
- Elimination Half-Life: 20-40 hours (longer in females than males).
- Extensive biotransformation via demethylation, oxidation, and conjugation.
- Excretion: Through urine and feces within four days.
Safety Advices
Alcohol
UNSAFE
Avoid consumption of alcohol while taking Mitaprex 15 as it may make you feel dizzier.
Pregnancy
CONSULT YOUR DOCTOR
Mitaprex 15 should be used with caution in pregnant women and in women who think that they might be pregnant or planning to have a baby. Therefore, consult your doctor before taking it.
Breastfeeding
CONSULT YOUR DOCTOR
Mitaprex 15 should be used with caution in breastfeeding women. Therefore, consult your doctor before taking it.
Driving
UNSAFE
Do not drive or operate any heavy tools or machines if you experience dizziness or tiredness after taking Mitaprex 15.
CONSULT YOUR DOCTOR
Mitaprex 15 should be used with caution in patients with kidney problems. Therefore, consult your doctor before taking it.
Liver
CONSULT YOUR DOCTOR
Mitaprex 15 should be used with caution in patients with liver problems (such as jaundice). Therefore, consult your doctor before taking it.
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✔️ Uses of Mitaprex 15
- Manage depression in adults
✔️ Dosage & Administration of Mitaprex 15
- Adults:
- Initial dose: 15 mg/day, preferably in the evening or before sleep.
- Effective range: 15-45 mg/day. Dose adjustments should be made at intervals of 1-2 weeks.
- Children: Not recommended for use.
- Missed Dose:
- Take as soon as remembered, unless it’s close to the next scheduled dose.
- Do not double doses.
✔️ Drug Interactions
- Monoamine Oxidase Inhibitors (MAOIs): Contraindicated within 14 days of MAOI use.
- Other Serotonergic Drugs: Tryptophan, SSRIs, venlafaxine, lithium, tramadol, triptans, and St. John's wort may increase the risk of serotonin syndrome.
- Carbamazepine, Phenytoin, Cimetidine: May alter metabolism of Mirtazapine.
- Alcohol & Diazepam: Should be avoided due to additive sedative effects.
✔️ Common Side Effects of Mitaprex 15
- Dizziness, drowsiness, dry mouth.
- Increased appetite, and weight gain.
✔️ Contraindications
- Hypersensitivity to Mirtazapine or any excipients.
- Concomitant use with MAOIs or within 14 days of MAOI initiation/discontinuation.
✔️ Pregnancy & Lactation
- Category C: Use only if the potential benefit justifies the risk to the fetus.
- Not recommended during breastfeeding without consulting a physician.
✔️ Precautions & Warnings
- Monitor for anxiety, agitation, suicidal ideation, and behavioral changes, especially at the start of treatment or during dose adjustments.
- Risk of agranulocytosis; watch for symptoms like fever or sore throat.
- Impaired motor skills and judgment due to sedative effects; caution patients about driving or operating machinery.
- Liver function: Clinically significant ALT elevations may occur.
✔️ Storage Conditions
- Store below 30°C, away from light and moisture.
- Keep out of reach of children.
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